Subscribe to RSS
DOI: 10.1055/a-2092-3913
Subjektive und objektivierte Riech- und Schmeckstörungen aus einer HNO-Post-COVID-19-Sprechstunde
Subjective and objectified smell and taste disorders from an ENT post-Covid-19 consultation
Zusammenfassung
Einleitung Riechstörungen gehören zu den 4 häufigsten Post-COVID-19-Beschwerden. Ziel unserer prospektiven Studie aus einer universitären HNO-Post-COVID-Sprechstunde (PCS) war es, die Beschwerden mit psychophysischen Testergebnissen zu untermauern.
Methoden Nach einer HNO-Untersuchung wurden 60 Post-COVID-19-Patienten (41 Frauen) schriftlich zu ihrer Krankengeschichte befragt. Ihre Riechfähigkeit wurde mit der erweiterten Sniffin’-Sticks-Testbatterie getestet, und ihr Schmeckvermögen wurde mit dem 3-Tropfen-Test bestimmt. Aus diesen Daten konnten 3 quantitative olfaktorische (RD) und gustatorische (SD) Diagnosen aus Normalwerttabellen definiert werden. Jeder zweite Patient nahm an einer Kontrolluntersuchung teil.
Ergebnisse Bis zur Erstuntersuchung gaben 60 Patienten Riech- und 51 Schmeckstörungen an; ihre durchschnittliche Dauer betrug in beiden Fällen 11 Monate. Objektivierte pathologische RD und SD hatten 87% bzw. 42% der Gesamtkohorte. Jeder dritte Patient litt an einer objektivierten Kombination aus olfaktorischen und gustatorischen Schäden. Etwa jeder zweite Patient klagte über eine Parosmie. Parosmische Patienten mit 2 Untersuchungsterminen kamen früher zur Kontrolle. Sechs Monate nach der Erstuntersuchung hatten sich bei diesen Patienten die Wahrnehmungsschwellen, der SDI und die RD verbessert. Die Selbsteinschätzung der Riechfähigkeit hatte sich nicht verändert.
Schlussfolgerungen Objektivierte pathologische RD persistierten in unserem PCS für durchschnittlich anderthalb Jahre seit Beginn der Infektion. Parosmiker hatten eine bessere Prognose. Für das Gesundheitssystem und insbesondere für die betroffenen Patienten stellen sie auch nach der Pandemie eine Belastung dar.
Abstract
Introduction Olfactory disorders are among the four most common post-COVID-19 complaints. The aim of our prospective study from a university ENT post-COVID consultation (PCS) was to substantiate the symptoms with psychophysical test results.
Methods After an ENT examination, 60 post-COVID-19 patients (41 women) were asked in writing about their medical history. Their ability to smell was tested using the extended Sniffin’ Sticks test battery and their ability to taste was determined using the 3-drop test. From these data, three quantitative olfactory (RD) and gustatory (SD) diagnoses could be defined from normal value tables. Every second patient took part in a control examination.
Results Up to the first examination, 60 patients reported smell and 51 taste disorders; their average duration was 11 months in both cases. Objectified pathologic RD and SD had 87% and 42% of the total cohort, respectively. Every third patient suffered from an objectified combination of olfactory and gustatory damage. About every second patient complained of parosmia. Parosmic patients with two visits came earlier for a check-up. Six months after the initial examination, the detection thresholds, the TDI and the RD had improved in these patients. The self-assessment of olfactory ability had not changed.
Conclusions Objectified pathologic RD persisted in our PCS for a mean of 1.5 years from the onset of infection. Parosmics had a better prognosis. For the healthcare system and especially for the patients affected, they continue to be a burden even after the pandemic.
Schlüsselwörter
Riechstörung - Schmeckstörung - psychophysische Messung des Riechens - psychophysische Messung des Schmeckens - Prognose des Riechvermögens - Prognose des Schmeckvermögens - Post-Covid-19 - SelbsteinschätzungKeywords
Post-Covid-19 - olfactory disorder - gustatory disorder - subjective rating - measured ability of smelling and tasting - prognosisPublication History
Received: 13 March 2023
Accepted after revision: 10 May 2023
Article published online:
20 June 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Lechien JR, Chiesa-Estomba CM, Vaira LA. et al. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients. European Archives of Oto-Rhino-Laryngology 2021; 278: 2851-2859
- 2 Lechien JR, Chiesa-Estomba CM, De Siati DR. et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-Rhino-Laryngology 2020; 1-11
- 3 Moein ST, Hashemian SM, Tabarsi P. et al. Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID-19 patients. International forum of allergy & rhinology: Wiley Online Library 2020; 1127-1135
- 4 Mazzatenta A, Neri G, D’Ardes D. et al. Smell and Taste in Severe COVID-19: Self-Reported vs. Testing. Front Med (Lausanne) 2020; 7: 589409
- 5 Lee Y, Min P, Lee S. et al. Prevalence and duration of acute loss of smell or taste in COVID-19 patients. Journal of Korean medical science 2020; 35
- 6 Tan BKJ, Han R, Zhao JJ. et al. Prognosis and persistence of smell and taste dysfunction in patients with COVID-19: meta-analysis with parametric cure modelling of recovery curves. BMJ 2022; 378: e069503
- 7 Lechien JR, Chiesa-Estomba CM, Hans S. et al. Loss of smell and taste in 2013 European patients with mild to moderate COVID-19. Annals of Internal Medicine 2020; 173: 672-675
- 8 Schulz M, Mangiapane S, Scherer M. et al. Post-acute sequelae of SARS-CoV-2 infection – characterization of community-treated patients in a case-control study based on nationwide claims data. Deutsches Arzteblatt international 2022; 119: 177-178
- 9 Ohla K, Veldhuizen MG, Green T. et al. Increasing incidence of parosmia and phantosmia in patients recovering from COVID-19 smell loss. Medrxiv 2021. 2021.2008. 2028.21262763.
- 10 Haehner A, Marquardt B, Kardashi R. et al. SARS-CoV-2 leads to significantly more severe olfactory loss than other seasonal cold viruses. Life 2022; 12: 461
- 11 Hummel T, Lötsch J. Prognostic factors of olfactory dysfunction. Archives of Otolaryngology–Head & Neck Surgery 2010; 136: 347-351
- 12 Liu DT, Sabha M, Damm M. et al. Parosmia is associated with relevant olfactory recovery after olfactory training. The Laryngoscope 2021; 131: 618-623
- 13 Menzel S, Haehner A, Woosch D. et al. Parosmia as a predictor of a better olfactory function in COVID-19: a multicentric longitudinal study for upper respiratory tract infections. European Archives of Oto-Rhino-Laryngology 2022; 1-10
- 14 Lerner DK, Garvey KL, Arrighi-Allisan AE. et al. Clinical features of parosmia associated with COVID-19 infection. The Laryngoscope 2022; 132: 633-639
- 15 Hummel T, Kobal G, Gudziol H. et al. Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 2007; 264: 237-243
- 16 Oleszkiewicz A, Schriever V, Croy I. et al. Updated Sniffin’ Sticks normative data based on an extended sample of 9139 subjects. European Archives of Oto-Rhino-Laryngology 2019; 276: 719-728
- 17 Gudziol V, Lotsch J, Hahner A. et al. Clinical significance of results from olfactory testing. Laryngoscope 2006; 116: 1858-1863
- 18 Gudziol H, Kirschstein T, Pletz MW. et al. High prevalence of long-term olfactory dysfunction confirmed by olfactory testing after a community COVID-19 outbreak. Hno 2022; 70: 224-231
- 19 Hummel T. Riechtraining nach COVID-19 beschleunigt die Erholung des ausgefallenen Geruchssinns. Accessed May 11, 2021 at: https://www.aerzteblatt.de/nachrichten/123785/Riechtraining-nach-COVID-19-beschleunigt-die-Erholung
- 20 Cohen J. Statistical Power 2nd Ed. Lawrence Erlbaum Associates; 1988
- 21 Eid M, Gollwitzer M, Schmitt M. Statistik und Forschungsmethoden Lehrbuch. In: . Beltz: Weinheim; 2011: 548
- 22 Lenhard W, Lenhard A. Berechnung von Effektstärken. Dettelbach: Psychometrica; 2016. In; 2021;
- 23 Peter RS, Nieters A, Kräusslich HG. et al. Post-acute sequelae of COVID-19 six to 12 months after infection: population based study. Bmj 2022; 379: e071050
- 24 Hintschich CA, Brosig A, Hummel T. et al. Gustatory Function in Acute COVID-19 – Results from Home-Based Psychophysical Testing. Laryngoscope 2022;
- 25 Berger U. Männer sterben früher, Frauen leiden mehr. Die Psychotherapie 2022; 67: 288-295
- 26 Cavazzana A, Larsson M, Münch M. et al. Postinfectious olfactory loss: a retrospective study on 791 patients. The Laryngoscope 2018; 128: 10-15
- 27 Juratli JH, Joshi A, Fussel S. et al. Gendered differences in relative ACE2 expression in the nasal epithelium. Rhinology 2022; 60: 471-473
- 28 Förster C, Colombo MG, Wetzel AJ. et al. Persisting symptoms after COVID-19-Prevalence and risk factors in a population-based cohort. Deutsches Arzteblatt international 2022; 119: 167-174
- 29 Rozin P. “Taste-smell confusions” and the duality of the olfactory sense. Percept Psychophys 1982; 31: 397-401
- 30 Gudziol H, Bitter T, Kirschstein T. et al. Reported and measured olfactory and gustatory findings in a long-COVID cohort. Laryngo-Rhino-Otol 2022;
- 31 Jensen MM, Larsen KD, Homøe AS. et al. Subjective and psychophysical olfactory and gustatory dysfunction among COVID-19 outpatients; short-and long-term results. PloS one 2022; 17: e0275518
- 32 Vaira LA, Salzano G, Petrocelli M. et al. Validation of a self-administered olfactory and gustatory test for the remotely evaluation of COVID-19 patients in home quarantine. Head & Neck 2020;
- 33 Boscolo-Rizzo P, Hummel T, Hopkins C. et al. High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation. Rhinology 2021; 59 (06) 517-527
- 34 Gudziol H, Rahneberg K, Burkert S. Anosmics are more poorly able to taste than normal persons. Laryngo-Rhino-Otol 2007; 86: 640-643
- 35 Lotsch J, Hummel T. The clinical significance of electrophysiological measures of olfactory function. Behavioural brain research 2006; 170: 78-83
- 36 Gudziol H, Baldow E, Guntinas-Lichius O. et al. Erkennungsraten von chemosensorisch evozierten Potenzialen bei gesunden und anosmischen Erwachsenen. Laryngo-Rhino-Otol 2020; 99: 803-810
- 37 Frasnelli J, Hummel T. Olfactory dysfunction and daily life. Eur Arch Otorhinolaryngol 2005; 262: 231-235
- 38 Raad N, Ghorbani J, Safavi Naeini A. et al. Parosmia in patients with COVID-19 and olfactory dysfunction. International Forum of Allergy & Rhinology: Wiley Online Library 2021; 1497-1500