Nuklearmedizinische Ultraschall-Fusionsbildgebung – Klinische Möglichkeiten und derzeitige Limitationen

Zusammenfassung

Die nuklearmedizinische Ultraschall-Fusionsbildgebung lässt sich unter anderem für die Diagnostik der Schilddrüse und Nebenschilddrüsen klinisch sinnvoll einsetzen und erlaubt die zweifelsfreie räumliche Korrelation metabolischer und morphologischer Informationen. Allerdings beschränkt sich die praktische Anwendung aufgrund derzeit noch limitierender Aspekte auf ausgewählte Fälle und wissenschaftliche Untersuchungen. Die Entwicklung eines integrierten hybriden Detektors zur simultanen nuklearmedizinisch-sonografischen Bildgebung wäre eine Möglichkeit, die bestehenden Limitationen zu überwinden.

Abstract

Ultrasound fusion imaging of nuclear medicine modalities can be used sufficiently for the diagnosis of thyroid and parathyroid diseases as well as for other indications. Therefore, it can contribute to an unambiguous spatial correlation between metabolic and morphologic information. However, its practical application is limited to selected cases and scientific purposes. The development of an integrated hybrid detector for simultaneous fusion imaging maybe helpful to overcome current limitations.

Schlüsselwörter

Ultraschall - Sonographie - Hybridbildgebung - Fusionsultraschall - Schilddrüsenbildgebung - Nebenschilddrüsenbildgebung

Keywords

Ultrasound - Sonography - Hybrid Imaging - Fusion Ultrasound - Thyroid Imaging - Parathyroid Imaging

• Literatur

• 1 Auer T, Heidegger I, De Zordo T. et al. Fusion Imaging of Contrast-enhanced Ultrasound With CT or MRI for Kidney Lesions. In Vivo 2019; 33: 203-208
• 2 Tewes S, Peters I, Tiemeyer A. et al. Evaluation of MRI/Ultrasound Fusion-Guided Prostate Biopsy Using Transrectal and Transperineal Approaches. Biomed Res Int 2017; 2017: 2176471
• 3 Theodore C, Levaillant JM, Capmas P. et al. MRI and Ultrasound Fusion Imaging for Cervical Cancer. Anticancer Res 2017; 37: 5079-5085
• 4 Freesmeyer M, Elsner P, Goetze S. et al. Positron emission tomography/ultrasound fusion technique in patients with malignant melanoma. J Med Imaging Radiat Oncol 2015; 59: 320-325
• 5 Freesmeyer M, Drescher R, Winkens T. Unexpected diagnosis of peripheral schwannoma on 18F-fluoroethylcholine PET/CT for localization of prostate cancer recurrence and biopsy under real-time PET/ultrasound fusion guidance. Clin Nucl Med 2014; 39: 385-386
• 6 Drescher R, Muller A, Lesser T. et al. PET/ultrasound fusion for differentiation of Vox implant silicone particles from recurrent cancer. Nuklearmedizin 2013; 52: N29-30
• 7 Garganese G, Bove S, Zagaria L. et al. Fusion of ultrasound and 3D single-photon-emission computed tomography/computed tomography to identify sentinel lymph nodes in vulvar cancer: feasibility study. Ultrasound Obstet Gynecol 2019; 54: 545-551
• 8 Freesmeyer M, Winkens T, Opfermann T. et al. Real-time ultrasound and freehand-SPECT. Experiences with sentinel lymph node mapping. Nuklearmedizin 2014; 53: 259-264
• 9 de Bree R, Pouw B, Heuveling DA. et al. Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer. AJNR Am J Neuroradiol 2015; 36: 2153-2158
• 10 Bluemel C, Safak G, Cramer A. et al. Fusion of freehand SPECT and ultrasound: First experience in preoperative localization of sentinel lymph nodes. Eur J Nucl Med Mol Imaging 2016; 43: 2304-2312
• 11 Garganese G, Bove S, Fragomeni S. et al. Real-time ultrasound virtual navigation in 3D PET/CT volumes for superficial lymph-node evaluation: innovative fusion examination. Ultrasound Obstet Gynecol 2021; 58: 766-772
• 12 Freesmeyer M, Weigel F, John U. et al. Real-Time DMSA-SPECT/US Fusion Imaging Revealing Nonscarring Loss of Function After Pyelonephritis. Clin Nucl Med 2020; 45: e274-e275
• 13 Gühne F, Weigel F, Kühnel C. et al. DMSA-camSPECT/US fusion imaging of children's kidneys – Proof of feasibility. Nuklearmedizin 2020; 59: 26-32
• 14 de Koekkoek-Doll PK, Maas M, Vogel W. et al. Real-Time Ultrasound Image Fusion with FDG-PET/CT to Perform Fused Image-Guided Fine-Needle Aspiration in Neck Nodes: Feasibility and Diagnostic Value. AJNR Am J Neuroradiol 2021; 42: 566-572
• 15 Liu Y, Yu H, Liu J. et al. A Pilot Study of (18)F-DCFPyL PET/CT or PET/MRI and Ultrasound Fusion Targeted Prostate Biopsy for Intra-Prostatic PET-Positive Lesions. Front Oncol 2021; 11: 612157
• 16 Okur A, Hennersperger C, Runyan B. et al. FhSPECT-US guided needle biopsy of sentinel lymph nodes in the axilla: is it feasible?. Med Image Comput Comput Assist Interv 2014; 17: 577-584
• 17 Beutler BD, Whang G, Tchelepi H. PET/CT Ultrasound Fusion for Percutaneous Biopsy: A Retrospective Single-Center Study and Review of the Literature. Clin Nucl Med 2022; 47: 692-698
• 18 Freesmeyer M, Gühne F. Clarification of a suspicious thyroid nodule by use of camSPECT/US fusion imaging. Endocrine 2017; 58: 199-200
• 19 Gühne F, Mothes H, Freesmeyer M. Allocation of parathyroid adenoma and suspicious thyroid nodule by real-time (99m)Tc-MIBI SPECT/US fusion imaging. Endocrine 2016; 54: 560-561
• 20 Leder T, Seifert P, Drescher R. et al. Excellent Response to Multimodal Therapy Approach in Hyperfunctioning Metastatic Follicular Thyroid Carcinoma Diagnosed on 123 I-SPECT/Ultrasound Fusion Imaging. Clin Nucl Med 2023; 48: 266-268
• 21 Seifert P, Greiser J, Winkens T. et al. Ectopic Retrolaryngeal Parathyroid Adenoma Detected by 18F-Ethylcholine PET/US Fusion Imaging. Clin Nucl Med 2022; 47: 182-184
• 22 Seifert P, Gühne F, Freesmeyer M. Hyperfunctioning Papillary Microcarcinoma Diagnosed by 124I PET/Ultrasound Fusion Imaging. Clin Nucl Med 2019; 44: 404-405
• 23 Seifert P, Winkens T, Kühnel C. et al. I-124-PET/US Fusion Imaging in Comparison to Conventional Diagnostics and Tc-99m Pertechnetate SPECT/US Fusion Imaging for the Function Assessment of Thyroid Nodules. Ultrasound Med Biol 2019; 45: 2298-2308
• 24 Freesmeyer M, Winkens T, Darr A. Diagnosis of small papillary thyroid cancer via sensor-navigated (124)iodine PET/ultrasound ((124)I-PET/US) fusion. J Clin Endocrinol Metab 2015; 100: 13-14
• 25 Freesmeyer M, Gühne F, Drescher R. et al. Multimodal Characterization of a PSMA-Positive Thyroid Nodule Using (68)Ga-PSMA and (124)Iodine PET/US Fusion Imaging. Diagnostics (Basel) 2022; 12: 472
• 26 Freesmeyer M, Opfermann T. Diagnosis of de quervain's subacute thyroiditis via sensor-navigated 124Iodine PET/ultrasound (124I-PET/US) fusion. Endocrine 2015; 49: 293-295
• 27 Gühne F, Winkens T, Mothes H. et al. Differential diagnosis of thyroid nodules via real-time PET/ultrasound (US) fusion in a case of co-existing medullary thyroid cancer and adenoma. J Clin Endocrinol Metab 2013; 98: 4250-4251
• 28 Freesmeyer M, Muller UA, Männel M. et al. Synchronous Metastatic Medullary Thyroid Carcinoma and Paraesophageal Parathyroid Adenoma Detected on 18 F-Ethylcholine PET/US Fusion Imaging. Clin Nucl Med 2022; 47: 977-979
• 29 Schenke S, Seifert P, Zimny M. et al. Risk Stratification of Thyroid Nodules Using the Thyroid Imaging Reporting and Data System (TIRADS): The Omission of Thyroid Scintigraphy Increases the Rate of Falsely Suspected Lesions. J Nucl Med 2019; 60: 342-347
• 30 Freesmeyer M, Winkens T, Weissenrieder L. et al. Fusion iENA Scholar Study: Sensor-Navigated I-124-PET/US Fusion Imaging versus Conventional Diagnostics for Retrospective Functional Assessment of Thyroid Nodules by Medical Students. Sensors (Basel) 2020; 20: 3409
• 31 Winkens T, Seifert P, Hollenbach C. et al. The FUSION iENA Study: Comparison of I-124-PET/US Fusion Imaging with Conventional Diagnostics for the Functional Assessment of Thyroid Nodules by Multiple Observers. Nuklearmedizin 2019; 58: 434-442
• 32 Bluemel C, Kirchner P, Kajdi GW. et al. Localization of Parathyroid Adenoma With Real-Time Ultrasound: Freehand SPECT Fusion. Clin Nucl Med 2016; 41: e141-142
• 33 Freesmeyer M, Opfermann T, Winkens T. Hybrid integration of real-time US and freehand SPECT: proof of concept in patients with thyroid diseases. Radiology 2014; 271: 856-861