Subscribe to RSS
DOI: 10.1055/a-1920-1831
Kognition bei Epilepsien im Kindes- und Jugendalter

ZUSAMMENFASSUNG
Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven Einschränkungen am stärksten. Die Erkennung von kognitiven Einschränkungen bei Kindern mit Epilepsie kann Auswirkungen auf entsprechende Förderkonzepte und Lebenswege für die betroffenen Kinder haben. Ferner muss erkannt werden, ob die medikamentöse Behandlung der Anfälle zu einer eingeschränkten kognitiven Leistungsfähigkeit beiträgt. In einigen Fällen können frühzeitige epilepsiechirurgische Eingriffe, sofern der Patient dafür infrage kommt, einen kognitiven Abbau aufhalten.
Publication History
Article published online:
08 November 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG,
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Bourgeois BF, Prensky AL, Palkes HS. et al Intelligence in epilepsy: a prospective study in children. Ann Neurol 1983; 14: 438-444
- 2 Cheung C, Wirrell E. Adolescents’ perception of epilepsy compared with other chronic diseases: “through a teenager’s eyes”. J Child Neurol 2006; 21: 214-222
- 3 Baca CB, Vickrey BG, Caplan R. et al Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics 2011; 128: e1532-1543
- 4 Fayed N, Davis AM, Streiner DL. et al Children’s perspective of quality of life in epilepsy. Neurology 2015; 84: 1830-1837
- 5 Berg AT, Baca CB, Rychlik K. et al Determinants of Social Outcomes in Adults With Childhood-onset Epilepsy. Pediatrics 2016: 137
- 6 Aldenkamp A, Besag F, Gobbi G. et al Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Adverse cognitive and behavioural effects of antiepileptic drugs in children. Epileptic Disord. 2016
- 7 Liang S, Wang S, Zhang J. et al Long-term outcomes of epilepsy surgery in school-aged children with partial epilepsy. Pediatr Neurol 2012; 47: 284-290
- 8 Lee YJ, Lee JS, Kang HC. et al Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy. Brain Dev 2014; 36: 496-504
- 9 Camfield P, Camfield C. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord 2015; 17: 117-123
- 10 Sorg AL, von Kries R, Borggraefe I.. Cognitive disorders in childhood epilepsy: a comparative longitudinal study using administrative healthcare data. J Neurol. 2022
- 11 Berg AT, Langfitt JT, Testa FM. et al Global cognitive function in children with epilepsy: a community-based study. Epilepsia 2008; 49: 608-614
- 12 Berg AT, Berkovic SF, Brodie MJ. et al Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010; 51: 676-685
- 13 Scheffer IE, Berkovic S, Capovilla G. et al ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017; 58: 512-521
- 14 Tacke M, Neubauer BA, Gerstl L. et al Epilepsy-new diagnostic tools, old drugs?: Therapeutic consequences of epilepsy genetics. Nervenarzt 2017; 88: 1385-1394
- 15 Willimsky EK, Munzig A, Mayer K. et al Next Generation Sequencing in Pediatric Epilepsy Using Customized Panels: Size Matters. Neuropediatrics 2021; 52: 92-97
- 16 Dravet C. The core Dravet syndrome phenotype. Epilepsia 2011; 52 (Suppl. 02) 3-9
- 17 Bender AC, Natola H, Ndong C. et al Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis 2013; 54: 297-307
- 18 de Lange IM, Gunning B, Sonsma ACM. et al Influence of contraindicated medication use on cognitive outcome in Dravet syndrome and age at first afebrile seizure as a clinical predictor in SCN1A-related seizure phenotypes. Epilepsia 2018; 59: 1154-1165
- 19 Nabbout R, Chemaly N, Chipaux M. et al Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy. Orphanet J Rare Dis 2013; 08: 176
- 20 Meador KJ. Cognitive outcomes and predictive factors in epilepsy. Neurology 2002; 58: S21-26
- 21 Moorhouse FJ, Cornell S, Gerstl L. et al Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents. Sci Rep 2020; 10: 21543
- 22 Lopes AF, Simoes MR, Monteiro JP. et al Intellectual functioning in children with epilepsy: frontal lobe epilepsy, childhood absence epilepsy and benign epilepsy with centro-temporal spikes. Seizure 2013; 22: 886-892
- 23 Nolan MA, Redoblado MA, Lah S. et al Intelligence in childhood epilepsy syndromes. Epilepsy Res 2003; 53: 139-150
- 24 Rzezak P, Guimaraes CA, Guerreiro MM. et al The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. Eur J Paediatr Neurol 2017; 21: 500-506
- 25 Besag FMC, Vasey MJ. Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy. Paediatr Drugs 2021; 23: 253-286
- 26 Boshuisen K, van Schooneveld MM, Uiterwaal CS. et al Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015; 78: 104-114
- 27 Loddenkemper T, Holland KD, Stanford LD. et al Developmental outcome after epilepsy surgery in infancy. Pediatrics 2007; 119: 930-935
- 28 Chan S, Pressler R, Boyd SG. et al Does sleep benefit memory consolidation in children with focal epilepsy?. Epilepsia 2017; 58: 456-466
- 29 Chan SY. Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective. Dev Med Child Neurol 2020; 62: 426-433
- 30 Tacke M, Rupp N, Gerstl L. et al Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology. Acta Neurol Scand 2018; 138: 475-481
- 31 Ng R, Hodges E. Neurocognitive Profiles of Pediatric Patients with ESES, Generalized Epilepsy, or Focal Epilepsy. Epilepsy Res 2020; 167: 106351
- 32 Groppel G, Dorfer C, Dressler A. et al Immediate termination of electrical status epilepticus in sleep after hemispherotomy is associated with significant progress in language development. Dev Med Child Neurol 2017; 59: 89-97
- 33 Nickels KC, Zaccariello MJ, Hamiwka LD. et al Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat Rev Neurol 2016; 12: 465-476
- 34 Metz-Lutz MN, Filippini M. Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome. Epilepsia 2006; 47 (Suppl. 02) 71-75
- 35 Parisi P, Bruni O, Pia Villa M. et al The relationship between sleep and epilepsy: the effect on cognitive functioning in children. Dev Med Child Neurol 2010; 52: 805-810
- 36 Vidaurre J, Twanow JDE. Attention Deficit Hyperactivity Disorder and Associated Cognitive Dysfunction in Pediatric Epilepsy. Semin Pediatr Neurol 2017; 24: 282291
- 37 Verrotti A, Moavero R, Panzarino G. et al The Challenge of Pharmacotherapy in Children and Adolescents with Epilepsy-ADHD Comorbidity. Clin Drug Investig 2018; 38: 1-8
- 38 Auvin S, Wirrell E, Donald KA. et al Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission. Epilepsia 2018; 59: 1867-1880
- 39 Noachtar S, Borggraefe I. Epilepsy surgery: a critical review. Epilepsy Behav 2009; 15: 66-72
- 40 Ramantani G, Kadish NE, Strobl K. et al Seizure and cognitive outcomes of epilepsy surgery in infancy and early childhood. Eur J Paediatr Neurol 2013; 17: 498-506
- 41 Helmstaedter C, Beeres K, Elger CE. et al Cognitive outcome of pediatric epilepsy surgery across ages and different types of surgeries: A monocentric 1-year follow-up study in 306 patients of school age. Seizure 2020; 77: 86-92