GLP-1-basierte Polypharmakotherapien als wegweisender neuer Ansatz in der Behandlung von Adipositas und Diabetes

Zusammenfassung

Die Prävalenz von Adipositas, Typ-2-Diabetes und dem metabolischen Syndrom nimmt weltweit dramatisch zu. Bestehende Therapieoptionen sind – mit Ausnahme der bariatrischen Chirurgie – nur unzureichend wirksam. Vielversprechende neue Ansätze zur nachhaltigen und effektiven Adipositastherapie basieren besonders auf biochemisch optimierten und langwirksamen Agonisten am Rezeptor für das glukagonähnliche Peptide-1 (GLP-1) sowie auf unimolekularen Ko-Agonisten an den Rezeptoren für GLP-1 und dem glukoseabhängigen insulinotropen Polypeptid (GIP). Jüngste klinische Studien belegen sowohl für den GLP-1R-Agonisten Semaglutid wie auch für den GIPR/GLP-1R-Ko-Agonisten Tirzepatide bei tolerablem Sicherheitsprofil einen Gewichtsverlust>10%.

Abstract

The prevalence of obesity, type 2 diabetes and metabolic syndrome is increasing dramatically worldwide. Existing treatment options – with the exception of bariatric surgery – are insufficiently effective. Promising new approaches to sustainable and effective obesity therapy are based in particular on biochemically optimized and long-acting agonists at the receptor for glucagon-like peptide-1 (GLP-1) and on unimolecular co-agonists at the receptors for GLP-1 and the glucose-dependent insulinotropic polypeptide (GIP). Recent clinical studies show a weight loss of>10% for both the GLP-1R agonist semaglutide and the GIPR/GLP-1R co-agonist tyrecepatide with a tolerable safety profile.

Schlüsselwörter

GLP-1 - GIP - Tirzepatide - Semaglutide - Ko-Agonisten

Key words

GLP-1 - GIP - tirzepatide - semaglutide - co-agonists

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