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Laryngorhinootologie 2023; 102(07): 488-495
DOI: 10.1055/a-1861-7379
Übersicht

Therapiekonzepte beim Schilddrüsenkarzinom

Therapy concepts for thyroid carcinoma
Friederike Eilsberger
1   Klinik für Nuklearmedizin, Universitätsklinikum Marburg, Marburg, Germany (Ringgold ID: RIN9377)
,
Michael C Kreissl
2   Abteilung für Nuklearmedizin, Universitätsklinikum Magdeburg, Magdeburg, Germany (Ringgold ID: RIN39067)
,
Markus Luster
3   Nuclearmedicine, University of Marburg, Marburg, Germany (Ringgold ID: RIN9377)
,
Andreas Pfestroff
1   Klinik für Nuklearmedizin, Universitätsklinikum Marburg, Marburg, Germany (Ringgold ID: RIN9377)
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Zusammenfassung

Die Theranostik über den Natrium-Iodid-Symporter (NIS) bietet bei differenzierten Schilddrüsenkarzinomen eine einzigartige Option. Die diagnostischen und therapeutischen Nuklide weisen eine übereinstimmende Aufnahme und Kinetik auf, sodass der NIS das wichtigste theranostische Target bei dieser Erkrankung darstellt. Radioiodrefraktäre Schilddrüsenkarzinome (RRTC) zeichnen sich durch eine verminderte/fehlende NIS-Expression aus, sodass diese Struktur als theranostisches Ziel entfällt. Auch aufgrund eingeschränkter therapeutischer Optionen gibt es Ansätze, bei RRTC über die Expression von Somatostatinrezeptoren (SSTR) oder das Prostata-spezifische-Membranantigen (PSMA) neue theranostische Targets zu generieren, jedoch lässt die aktuelle Studienlage eine endgültige Bewertung der Erfolgsaussichten noch nicht zu.

Abstract

Theranostics via the sodium iodide symporter (NIS) offer a unique option in differentiated thyroid carcinoma. The diagnostic and therapeutic nuclides have similar uptake and kinetics, making the NIS the most important theranostic target in this disease. Radioiodine refractory thyroid carcinomas (RRTC) are characterised by reduced/absent NIS expression, thus eliminating this structure as a theranostic target. Also due to limited therapeutic options, there are approaches to generate new theranostic targets in RRTC, via the expression of somatostatin receptors (SSTR) or the prostate-specific membrane antigen (PSMA), but the current evidence does not yet allow a final evaluation of the prospects of success.

Schlüsselwörter

radioiodrefraktär - PSMA - SSTR

Keywords

thyroid cancer - Schilddrüsenkarzinom - Natrium-Iodid-Symporter


Publication History

Received: 01 September 2021

Accepted: 15 September 2021

Article published online:
03 April 2023

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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