Voluntary Increase of Minute Ventilation for Prevention of Acute Mountain Sickness

Abstract

This study evaluated the feasibility and efficacy of voluntary sustained hyperventilation during rapid ascent to high altitude for the prevention of acute mountain sickness (AMS). Study subjects (n=32) were volunteer participants in a 2-day expedition to Mount Leoneras (4954 m), starting at 2800m (base camp at 4120 m). Subjects were randomized to either: 1) an intervention group using the voluntary hyperventilation (VH) technique targeting an end-tidal CO₂ (ETCO₂)<20 mmHg; or 2) a group using acetazolamide (AZ). During the expedition, respiratory rate (28±20 vs. 18±5 breaths/min, mean±SD, P<0.01) and SpO₂ (95%±4% vs. 89%±5%, mean±SD, P<0.01) were higher, and ETCO₂ (17±4 vs. 26±4 mmHg, mean±SD, P<0.01) was lower in the VH group compared to the AZ group – as repeatedly measured at equal fixed intervals during the ascent – showing the feasibility of the VH technique. Regarding efficacy, the incidence of 6 (40%) subjects registering an LLS score≥3 in the VH group was non-inferior to the 3 (18%) subjects in the acetazolamide group (P=0.16, power 28%). Voluntary increase in minute ventilation is a feasible technique, but – despite the underpowered non-inferiority in this small-scale proof-of-concept trial – it is not likely to be as effective as acetazolamide to prevent AMS.

Key words

high attitude illness - hyperventilation - hypobaric hypoxia

Publication History

Received: 29 September 2021

Accepted: 11 April 2022

Article published online:
27 June 2022

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