Abstract
This study was aimed to investigate the effect of weight loss by bariatric
surgery on the level of anti-Mullerian hormone (AMH) in morbidly obese female
patients with or without polycystic ovary syndrome (PCOS). This prospective
study includes 70 females, obese, and fertile patients of reproductive age. All
patients were evaluated to determine the changes in weight, body mass index
(BMI), serum AMH, and other biochemical parameters at the end of six months. The
mean levels of the preop and postop AMH were
1.66±0.87 ng/ml and
5.99±1.39 ng/ml in the PCOS group;
1.35±0.76 ng/ml and
6.23±1.47 ng/ml in the non-PCOS group, respectively. The
postop AMH levels were significantly higher than the preop levels for both
groups (p<0.001). There were significant differences in the level of
glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL),
triglyceride, total cholesterol, hemoglobin A1c, HOMA-IR, insulin between preop
and postop 6th month. A negative correlation was found between postop AMH and
body weight in all patients (r=–0.337, p=0.031). Postop
AMH levels were negatively correlated with postop BMI levels in the non-PCOS
patient group (r=–0.408, p=0.043). No significant
difference was observed between the PCOS and non-PCOS groups in terms of all the
parameters examined. In conclusion, our study suggests that the significantly
increased AMH levels by losing weight with bariatric surgery in patients with
morbid obesity with and without PCOS may indicate the improvement of
fertilization potential. It could be considered when evaluating fertility in
patients with morbid obesity.
Key words
infertility - polycystic ovary syndrome - reproductive functions - weight loss
