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Int J Sports Med 2022; 43(05): 455-465
DOI: 10.1055/a-1678-7147
Genetics and Molecular Biology

Regulation of the Effect of Physical Activity Through MicroRNAs in Breast Cancer

Bok Sil Hong
1   Cheju Halla University, Life Science Research Center, Department of Nursing, Jeju, Korea (the Republic of)
› Author Affiliations Funding This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF- 2019R1H1A1035588, and NRF-2020R1F1A1049665).
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Correction: Regulation of the Effect of Physical Activity Through MicroRNAs in Breast CancerInt J Sports Med 2022; 43(05): 465-465
DOI: 10.1055/a-1770-7074

Abstract

Physical activity and exercise can induce beneficial molecular and biological regulations that have been associated with an incidence of various diseases, including breast cancer. Recent studies demonstrated that the potential links between physical activity-induced circulating microRNAs (miRNAs) and cancer risk and progression. Here, we investigated whether altered miRNAs by exercise could influence breast cancer progression. After primary searching in PubMed and reviewing the full-text papers, candidate miRNAs altered by exercise in breast cancer were identified. Analysis of expression profiles and clinical outcomes of altered miRNAs using The Cancer Genome Atlas datasets showed altered miRNAs expressions were significantly associated with the patient's prognosis, whereas prognostic values of each miRNA varied in different stages and subtypes. In addition, altered miRNAs profiles regulated various target genes and key signaling pathways in tumorigenesis, including pathways in cancer and the PI3K-Akt signaling pathway; however, miRNAs regulated the expression of target genes differently according to tumor stages and subtypes. These results indicate that circulating miRNAs are promising noninvasive stable biomarkers for early detection, diagnosis, prognosis, and monitoring the response to clinical therapies of breast cancer. Moreover, stages and subtype-stratified approaches for breast cancer progression would be needed to evaluate the prognostic value of miRNAs for biomarkers and therapeutic targets.

Key words

circulating miRNAs - exercise - biomarker - prognosis

Supplementary Material



Publication History

Received: 02 April 2021

Accepted: 13 October 2021

Article published online:
06 December 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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