Senologie - Zeitschrift für Mammadiagnostik und -therapie 2021; 18(04): 365-376
DOI: 10.1055/a-1678-1129
Übersicht

Liquid Biopsy beim Mammakarzinom

Liquid Biopsy in Breast Cancer
Maggie Banys-Paluchowski
1   Frauenklinik, Asklepios Klinik Barmbek, Hamburg
,
Natalia Krawczyk
2   Universitäts-Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf
,
Tanja Fehm
2   Universitäts-Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf
› Author Affiliations

Zusammenfassung

In den letzten Jahren gewinnt die Liquid Biopsy, d. h. die blutbasierte Untersuchung von zirkulierenden Tumorzellen (CTCs) und Nukleinsäuren (DNA/RNA) beim Mammakarzinom zunehmend an Relevanz. Zahlreiche Studien haben bereits die hohe prognostische Bedeutung der CTC-Detektion sowohl im frühen als auch metastasierten Stadium gezeigt. Des Weiteren korrelieren die Veränderungen der CTC-Zahlen und der zirkulierenden Tumor-DNA (ctDNA) im Verlauf der Erkrankung mit dem Ansprechen auf die Therapie. Im Fokus der Forschung stehen derzeit die Liquid-Biopsy-basierten Therapieinterventionen beim metastasierten Mammakarzinom. In diesem Kontext wurde Alpelisib, ein PI3K-Inhibitor, als erste Substanz durch die FDA und die EMA zugelassen.

Abstract

In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and metastatic stages. Moreover, the changes in CTC levels and circulating tumour DNA (ctDNA) during the course of the disease correlate with the response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions in metastatic breast cancer. In this context, alpelisib, a PI3K inhibitor, was the first agent to be approved by FDA and EMA.



Publication History

Received: 29 June 2020

Accepted: 02 August 2020

Article published online:
14 December 2021

© 2020. This article was originally published by Thieme as Maggie Banys-Paluchowski et al., Liquid Biopsy in Breast Cancer. Geburtsh Frauenheilk 2020; 80: 1093–1104 as an open access article under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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