Abstract
Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with
obesity, which is a common complication associated with lower extremity atherosclerotic
disease (LEAD). However, to date, the relationship between elevated WISP1 levels and
the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes
mellitus (T2DM) remains unclear.
Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients
were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric
parameters, blood pressure and some biochemical parameters were obtained. Body composition
was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were
determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined
using an enzyme-linked immunosorbent assay.
Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than
those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for
LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the
highest tertile after adjusting confounding factors.
Conclusion The results suggest that increased serum WISP1 levels independently contribute to
the incidence of LEAD in patients with newly diagnosed T2DM.
Key words
Wnt1-induced signaling pathway protein 1 - lower extremity atherosclerotic disease
- type 2 diabetes mellitus - obesity - inflammation - insulin resistance
