Planta Med 2021; 87(10/11): 907-912
DOI: 10.1055/a-1386-8848
Biological and Pharmacological Activity
Original Papers

Ginger (Zingiber officinale) Root Extract During Pregnancy: A Clinical Feasibility Study[ # ]

Gert Maria Laekeman
1   Faculty of Pharmaceutical Sciences, KULeuven, Belgium
,
Kristel Van Calsteren
2   Department of Gynecology and Obstetrics, UZ Gasthuisberg, Belgium
,
Roland Devlieger
2   Department of Gynecology and Obstetrics, UZ Gasthuisberg, Belgium
,
Ekaterina Sarafanova
1   Faculty of Pharmaceutical Sciences, KULeuven, Belgium
,
Jonice Van Limbeek
3   Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
,
Yvan Dierckxsens
4   Laboratoires Tilman, Baillonville, Belgium
› Author Affiliations
Supported by: Laboratoires Tilman Baillonville Belgium

Abstract

There is almost no experience with concentrated ginger extracts during pregnancy. The purpose of this trial was to include 50 pregnant women in a clinical feasibility study with EXT.GR10, a 10 × concentrated ethanolic extract of ginger root. The primary objective was to detect complications in the mother during pregnancy and malformations or complications in the newborn at delivery. The secondary purpose was to evaluate the satisfaction of the patients. In total, 51 pregnant women were included in this observational study. They could freely use ginger tablets with a maximum of 2 tablets of 50 mg EXT.GR10 a day in case of gastrointestinal discomfort. Tablets were taken by 44 patients. Stillbirth, prematurity, hypertension, and gestational diabetes occurred. There were no serious complications at birth. In the newborn, 4 cases of dysplasia of the hip were seen and 2 minor malformations. There was no relation between events affecting mother and child and the number of EXT.GR10 tablets taken. About ⅔ of patients appreciated the effects of ginger. This is the first clinical study with the EXT.GR10 extract. Based on this feasibility study, a follow-up clinical trial is planned with a fixed minimum of exposure to EXT.GR10 during the first trimester of pregnancy.

# Dedicated to Professor Arnold Vlietinck on the occasion of his 80th birthday.


Supporting Information



Publication History

Received: 31 August 2020

Accepted after revision: 07 February 2021

Article published online:
11 March 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
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