The transCampus Metabolic Training Programme Explores the Link of
                    SARS-CoV-2 Virus to Metabolic Disease

S. R. Bornstein; K. Guan; C. Brunßen; G. Mueller; V. Kamvissi-Lorenz; R. Lechler; R. Trembath; M. Mayr; L. Poston; R. Sancho; S. Ahmed; E. Alfar; B. Aljani; T. C. Alves; S. Amiel; C. L. Andoniadou; M. Bandral; A. Belavgeni; I. Berger; A. Birkenfeld; E. Bonifacio; T. Chavakis; P. Chawla; P. Choudhary; A. M. Cujba; L. F. Delgadillo Silva; T. Demcollari; D. M. Drotar; S. Duin; N. N. El-Agroudy; A. El-Armouche; A. Eugster; M. Gado; A. Gavalas; M. Gelinsky; M. Guirgus; S. Hansen; E. Hanton; M. Hasse; H. Henneicke; C. Heller; H. Hempel; C. Hogstrand; D. Hopkins; L. Jarc; P. M. Jones; M. Kamel; S. Kämmerer; A. J. F. King; A. Kurzbach; C. Lambert; Y. Latunde-Dada; I. Lieberam; J. Liers; J. W. Li; A. Linkermann; S. Locke; B. Ludwig; T. Manea; F. Maremonti; Z. Marinicova; B. M. McGowan; M. Mickunas; G. Mingrone; K. Mohanraj; H. Morawietz; N. Ninov; M. Peakman; S. J. Persaud; J. Pietzsch; E. Cachorro; T. J. Pullen; I. Pyrina; F. Rubino; A. Santambrogio; F. Schepp; P. Schlinkert; L. D. Scriba; R. Siow; M. Solimena; F. M. Spagnoli; S. Speier; A. Stavridou; C. Steenblock; A. Strano; P. Taylor; A. Tiepner; W. Tonnus; T. Tree; F. Watt; M. Werdermann; M. Wilson; N. Yusuf; C. G. Ziegler; IRTG Study Group:

doi:10.1055/a-1377-6583

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Horm Metab Res 2021; 53(03): 204-206
DOI: 10.1055/a-1377-6583

Commentary

The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

Authors

S. R. Bornstein

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

²Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

³University Hospital Zurich, Department of Endocrinology and Diabetology, Zurich, Switzerland

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
K. Guan

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
C. Brunßen

⁶Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
G. Mueller

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
V. Kamvissi-Lorenz

²Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
R. Lechler

⁷King’s College London, London, UK
R. Trembath

⁸Department of Medical & Molecular Genetics, King’s College London, London, UK
M. Mayr

⁹School of Cardiovascular Medicine and Science, Faculty of Life Science & Medicine, KCL, London, UK
L. Poston

¹⁰Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
R. Sancho

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK

IRTG Study Group:

S. Ahmed

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
E. Alfar

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
B. Aljani

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
T. C. Alves

¹³Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
S. Amiel

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
C. L. Andoniadou

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

¹⁵Craniofacial Development and Stem Cell Biology, KCL, London, UK
M. Bandral

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
A. Belavgeni

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
I. Berger

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
A. Birkenfeld

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

²Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

¹⁶Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
E. Bonifacio

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
T. Chavakis

¹³Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
P. Chawla

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
P. Choudhary

²Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
A. M. Cujba

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
L. F. Delgadillo Silva

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
T. Demcollari

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
D. M. Drotar

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
S. Duin

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

¹⁷Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universität Dresden, Dresden, Germany
N. N. El-Agroudy

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
A. El-Armouche

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
A. Eugster

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
M. Gado

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
A. Gavalas

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
M. Gelinsky

¹⁷Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universität Dresden, Dresden, Germany
M. Guirgus

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
S. Hansen

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
E. Hanton

¹⁸Peter Gorer Department of Immunobiology, Guy’s Hospital, London, UK
M. Hasse

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
H. Henneicke

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
C. Heller

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
H. Hempel

⁶Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
C. Hogstrand

¹⁹Department of Nutritional Sciences, Faculty of Life Sciences & Medicine, KCL, London, UK
D. Hopkins

²⁰Department of Diabetic Medicine, King’s College Hospital NHS Foundation Trust and KCL, London, UK
L. Jarc

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
P. M. Jones

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
M. Kamel

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
S. Kämmerer

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
A. J. F. King

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
A. Kurzbach

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
C. Lambert

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
Y. Latunde-Dada

⁷King’s College London, London, UK
I. Lieberam

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
J. Liers

²¹Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
J. W. Li

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
A. Linkermann

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
S. Locke

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
B. Ludwig

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

³University Hospital Zurich, Department of Endocrinology and Diabetology, Zurich, Switzerland

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
T. Manea

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
F. Maremonti

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
Z. Marinicova

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
B. M. McGowan

²²Department of Diabetes and Endocrinology, London, UK
M. Mickunas

¹⁸Peter Gorer Department of Immunobiology, Guy’s Hospital, London, UK
G. Mingrone

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

²³Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

²⁴Università Cattolica del Sacro Cuore, Rome, Italy
K. Mohanraj

¹³Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
H. Morawietz

⁶Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
N. Ninov

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
M. Peakman

¹⁸Peter Gorer Department of Immunobiology, Guy’s Hospital, London, UK
S. J. Persaud

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
J. Pietzsch

²¹Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
E. Cachorro

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
T. J. Pullen

²⁵School of Life Course Sciences, Faculty of Life Sciences & Medicine, KCL, London, UK
I. Pyrina

¹³Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
F. Rubino

¹⁴Department of Diabetes Research, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
A. Santambrogio

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
F. Schepp

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
P. Schlinkert

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
L. D. Scriba

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
R. Siow

²⁶Vascular Biology & Inflammation Section, School of Cardiovascular Medicine & Sciences, British Heart Foundation of Research Excellence, King’s College London, London, UK
M. Solimena

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany

²⁷Molecular Diabetology, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany
F. M. Spagnoli

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
S. Speier

⁴Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany
A. Stavridou

¹²Center for Regenerative Therapies Dresden, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
C. Steenblock

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
A. Strano

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
P. Taylor

¹⁰Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
A. Tiepner

⁵Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
W. Tonnus

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
T. Tree

¹⁸Peter Gorer Department of Immunobiology, Guy’s Hospital, London, UK
F. Watt

¹¹Centre for Stem Cells and Regenerative Medicine, King’s College London, London, UK
M. Werdermann

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany
M. Wilson

²⁵School of Life Course Sciences, Faculty of Life Sciences & Medicine, KCL, London, UK
N. Yusuf

¹⁸Peter Gorer Department of Immunobiology, Guy’s Hospital, London, UK
C. G. Ziegler

¹ Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

Funding Funding was provided by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project Number 288034826 – IRTG: 2251 (SRB).

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Abstract

Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter our cells causing damage and disease. Our international research training programme funded by the German Research Foundation has a clear mission to train the best students wherever they may come from to learn to tackle the enormous challenges of diabetes and its complications for our society. A modern training programme in diabetes and metabolism does not only involve a thorough understanding of classical physiology, biology and clinical diabetology but has to bring together an interdisciplinary team. With the arrival of the coronavirus pandemic, this prestigious and unique metabolic training programme is facing new challenges but also new opportunities. The consortium of the training programme has recognized early on the need for a guidance and for practical recommendations to cope with the COVID-19 pandemic for the community of patients with metabolic disease, obesity and diabetes. This involves the optimal management from surgical obesity programmes to medications and insulin replacement. We also established a global registry analyzing the dimension and role of metabolic disease including new onset diabetes potentially triggered by the virus. We have involved experts of infectious disease and virology to our faculty with this metabolic training programme to offer the full breadth and scope of expertise needed to meet these scientific challenges. We have all learned that this pandemic does not respect or heed any national borders and that we have to work together as a global community. We believe that this transCampus metabolic training programme provides a prime example how an international team of established experts in the field of metabolism can work together with students from all over the world to address a new pandemic.

Key words

COVID-19 - transCampus - metabolic training programme

Publication History

Received: 22 January 2021

Accepted after revision: 23 January 2021

Article published online:
02 March 2021

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

References
1 Bornstein SR, Dalan R, Hopkins D. et al. Endocrine and metabolic link to coronavirus infection. Nat Rev Endocrinol 2020; 16: 297-298

Reference Link Ris
Crossref PubMed Search in Google Scholar
2 Mallapaty S. Mounting clues suggest the coronavirus might trigger diabetes. Nature 2020; 583: 16-17

Reference Link Ris
Crossref PubMed Search in Google Scholar
3 Mitchell F. transCampus London-Dresden: A new model for international collaborative research. Lancet Diabetes Endocrinol 2017; 5: 939

Reference Link Ris
Crossref PubMed Search in Google Scholar
4 Ludwig B, Ludwig S, Steffen A. et al. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci USA 2017; 114: 11745-11750

Reference Link Ris
Crossref PubMed Search in Google Scholar
5 Cohrs CM, Panzer JK, Drotar DM. et al. Dysfunction of persisting beta cells is a key feature of early type 2 diabetes pathogenesis. Cell Rep 2020; 31: 107469

Reference Link Ris
Crossref PubMed Search in Google Scholar
6 Bornstein SR, Rubino F, Khunti K. et al. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol 2020; 8: 546-550

Reference Link Ris
Crossref PubMed Search in Google Scholar
7 Rubino F, Amiel SA, Zimmet P. et al. New-Onset Diabetes in COVID-19. N Engl J Med 2020; 383: 789-790

Reference Link Ris
Crossref PubMed Search in Google Scholar
8 Hollstein T, Schulte DM, Schulz J. et al. Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: A case report. Nat Metab 2020; 2: 1021-1024

Reference Link Ris
Crossref PubMed Search in Google Scholar
9 Steenblock C, Todorov V, Kanczkowski W. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis. Mol Psychiatry 2020; 25: 1611-1617

Reference Link Ris
Crossref PubMed Search in Google Scholar
10 Barthel A, Mohanraj K, Biener AM. et al. Metabolic Syndrome and COVID-19: Endocrine-immune vascular interactions shape the clinical course. Endocrinology 2020; 161 bqaa131

Reference Link Ris
PubMed Search in Google Scholar
11 Tonn T, Corman VM, Johnsen M. et al. Stability and neutralising capacity of SARS-CoV-2-specific antibodies in convalescent plasma. Lancet Microbe 2020; 1: e63

Reference Link Ris
Crossref PubMed Search in Google Scholar
12 Mayr M, Gutmann C, Takov K. et al. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. Preprint,

Reference Link Ris
Crossref PubMed

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