Lebensqualität und Lebensverlängerung durch endokrin kombinierte Tumortherapie

Im Zentrum der medikamentösen Systemtherapie des metastasierten Mammakarzinoms stehen die Symptomkontrolle, die Verlängerung des Überlebens sowie die Lebensqualität der Patientinnen. Daher ist die endokrine Therapie mit ihrem günstigeren Nebenwirkungsprofil die Erstlinientherapie der Wahl bei Hormonrezeptorpositivität. Die antihormonelle Therapie kann als Monotherapie oder in Kombination mit zielgerichteten Substanzen eingesetzt werden.

Schlüsselwörter

Hormonrezeptorpositives metastasiertes Mammakarzinom - Endokrine Therapie - CDK4/6i - PI3K/AKT/mTOR - Signaltransduktionsweg - Biomarker

• Literatur

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