Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity

Mikio Doi; Naoki Morita; Tsugumi Okuzawa; Satoru Ohgiya; Daisaku Okamoto; Kenichi Sato; Yukiya Ito; Hideyuki Matsuura; Yasuyuki Hashidoko

doi:10.1055/a-1345-9471

Planta Medica, Table of Contents

Planta Med 2022; 88(06): 440-446
DOI: 10.1055/a-1345-9471

Natural Product Chemistry and Analytical Studies

Original Papers

Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity

Mikio Doi‡

¹Graduate School of Agriculture, Hokkaido University, Japan

,

Naoki Morita‡

²Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Hokkaido, Japan

,

Tsugumi Okuzawa

²Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Hokkaido, Japan

,

Satoru Ohgiya

³National Institute of Advanced Industrial Science and Technology, AIST Hokkaido, Hokkaido, Japan

,

Daisaku Okamoto

⁴Plant Breeding Institute, Hokkaido, Japan

,

Kenichi Sato

⁵Northern Advancement Center for Science and Technology, Hokkaido, Japan

,

Yukiya Ito

⁵Northern Advancement Center for Science and Technology, Hokkaido, Japan

,

Hideyuki Matsuura

¹Graduate School of Agriculture, Hokkaido University, Japan

,

Yasuyuki Hashidoko

¹Graduate School of Agriculture, Hokkaido University, Japan

› Author Affiliations

Abstract

Quercetin, a flavonol, is a functional compound that is abundant in onions and is known to have antioxidant and anti-inflammatory effects. Quercetin and its glucoside are known to function as peroxisome proliferator-activated receptor (PPAR) ligands and showed high PPAR-α transactivation activity but little PPAR-γ transactivation activity in some reports. In this study, we demonstrated that an aqueous extract of a quercetin-rich onion cultivar increased transactivation activities not only of PPAR-α but also of PPAR-γ. We isolated (9S,12S,13S)-(10E)-9,12,13-trihydroxyoctadec-10-enoic acid (pinellic acid) obtained from the aqueous extract using PPAR-γ transactivation as an index. Furthermore, it was revealed that pinellic acid could transactivate PPAR-α. Our findings are the first report mentioned showing that trihydroxyoctadec-10-enoic acids showed PPAR-α/γ transactivation activities.

Key words

Allium cepa - Amaryllidaceae - (9S,12S,13S)-(10E)-9,12,13-Trihydroxyoctadec-10-enoic acid (Pinellic acid) - (S) configuration - peroxisome proliferator-activated receptor - nuclear factor-κB

Full Text

References

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