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Int J Sports Med 2021; 42(01): 33-40
DOI: 10.1055/a-1186-1009
Physiology & Biochemistry

Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients

Anasua Pal
1   Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
2   Division of Physical Activity, Prevention and Cancer, National Center of Tumor Diseases, Heidelberg, Germany
,
Philipp Zimmer
3   Institute of Cardiovascular Research and Sports Medicine; Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
4   (G210) Department for Physical Activity, Preventive Research and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
,
Dorothea Clauss
1   Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
2   Division of Physical Activity, Prevention and Cancer, National Center of Tumor Diseases, Heidelberg, Germany
5   Division of Medical Oncology, University Hospital Heidelberg Medical Clinic, Heidelberg, Germany
,
Martina E. Schmidt
1   Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
,
Cornelia M. Ulrich
6   Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, United States
,
Joachim Wiskemann
7   Medical Oncology, Heidelberg Cancer Center, Heidelberg, Germany
,
Karen Steindorf
1   Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
› Author Affiliations Funding: The SUPPORT trial was supported by a grant of the German Caner Aid (Grant No. 110513 and 110552) as well as by additional financial support of the German Cancer Research Center and the University Hospital Heidelberg. Biospecimen storage was further supported by the infrastructure of the NCT Liquid Biobank.
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Abstract

The aim of this study was to investigate the impact of Supervised and Home-based resistance exercise on the Kynurenine pathway in patients with pancreatic cancer who underwent surgery and chemotherapy. In the SUPPORT study, adult pancreatic cancer patients were randomized to intervention programs of 6-month (1) a Supervised moderate-to-high-intensity progressive resistance training or (2) unsupervised Home-based resistance training, or (3) to a standard care patient Control group. Serum levels of kynurenine, tryptophan and IL-6 were assessed for 32 participants before, after 3 months and after 6 months of exercise intervention. Group differences were investigated using analysis-of-covariance. Patients in the Supervised training group showed decreased levels of serum kynurenine and kynurenine/tryptophan ratio (p = 0.07; p = 0.01 respectively) as well as increased Tryptophan levels (p = 0.05) in comparison to Home-based and Control group over time. The Home-based exercise group had significant increased kynurenine and kynurenine/tryptophan ratio levels. IL-6 levels decreased over the first three months for both intervention groups as well as the Control group (Supervised: p < 0.01, Home-based: p < 0.010, Control group: p < 0.01). Supervised resistance exercise might positively regulate the Kynurenine pathway and downregulate the kynurenine/tryptophan (indicative of IDO/TDO enzyme) levels, hence modulating the immune system.

Key words

exercise - cancer - physical activity - kynurenine - tryptophan - IDO/TDO

Supplementary Material



Publication History

Received: 08 January 2020

Accepted: 14 May 2020

Article published online:
24 July 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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