Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer
Patients

Anasua Pal; Philipp Zimmer; Dorothea Clauss; Martina E. Schmidt; Cornelia M. Ulrich; Joachim Wiskemann; Karen Steindorf

doi:10.1055/a-1186-1009

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2021; 42(01): 33-40
DOI: 10.1055/a-1186-1009

Physiology & Biochemistry

Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients

Anasua Pal

¹Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

²Division of Physical Activity, Prevention and Cancer, National Center of Tumor Diseases, Heidelberg, Germany

,

Philipp Zimmer

³Institute of Cardiovascular Research and Sports Medicine; Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany

⁴(G210) Department for Physical Activity, Preventive Research and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

,

Dorothea Clauss

¹Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

²Division of Physical Activity, Prevention and Cancer, National Center of Tumor Diseases, Heidelberg, Germany

⁵Division of Medical Oncology, University Hospital Heidelberg Medical Clinic, Heidelberg, Germany

,

Martina E. Schmidt

¹Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

,

Cornelia M. Ulrich

⁶Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, United States

,

Joachim Wiskemann

⁷Medical Oncology, Heidelberg Cancer Center, Heidelberg, Germany

,

Karen Steindorf

¹Division of Physical Activity, Prevention and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

› Author Affiliations

Abstract

The aim of this study was to investigate the impact of Supervised and Home-based resistance exercise on the Kynurenine pathway in patients with pancreatic cancer who underwent surgery and chemotherapy. In the SUPPORT study, adult pancreatic cancer patients were randomized to intervention programs of 6-month (1) a Supervised moderate-to-high-intensity progressive resistance training or (2) unsupervised Home-based resistance training, or (3) to a standard care patient Control group. Serum levels of kynurenine, tryptophan and IL-6 were assessed for 32 participants before, after 3 months and after 6 months of exercise intervention. Group differences were investigated using analysis-of-covariance. Patients in the Supervised training group showed decreased levels of serum kynurenine and kynurenine/tryptophan ratio (p = 0.07; p = 0.01 respectively) as well as increased Tryptophan levels (p = 0.05) in comparison to Home-based and Control group over time. The Home-based exercise group had significant increased kynurenine and kynurenine/tryptophan ratio levels. IL-6 levels decreased over the first three months for both intervention groups as well as the Control group (Supervised: p < 0.01, Home-based: p < 0.010, Control group: p < 0.01). Supervised resistance exercise might positively regulate the Kynurenine pathway and downregulate the kynurenine/tryptophan (indicative of IDO/TDO enzyme) levels, hence modulating the immune system.

Key words

exercise - cancer - physical activity - kynurenine - tryptophan - IDO/TDO

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References

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Supplementary Material

Supplementary Material