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Klin Padiatr 2020; 232(06): 328-330
DOI: 10.1055/a-1183-4686
Diagnostic and Treatment Recommendation

A Case Report of Dendritic Fibromyxolipoma in the Back of Pediatric Patient

Fallbericht über ein dendritisches Fibromyxolipom im Rücken einer Patientin der Pädiatrie
Yanling Jin
1   Pathology, First Affiliated Hospital of Dalian Medical University, Dalian, China
,
Lizhi Zhang
1   Pathology, First Affiliated Hospital of Dalian Medical University, Dalian, China
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Abstract

Objective To investigate the pathologic features and differential diagnosis of a pediatric dendritic fibromyxolipoma (DFML).

Methods We collected one case of dendritic fibromyxolipoma in the back of a pediatric patient (6 years old, female) diagnosed at the First Affiliated Hospital of Dalian Medical University. The case of DFML was studied by H&E and MaxVision immunohistochemical staining. The clinical and pathological features were analyzed with review of the literatures

Results The tumor was round or ovoid in shape and appeared in the surface of back. Microscopically, the tumor was mainly consisted of stellate to spindle cells, rope-like collagen fibers and varying amount of mature lipocytes embedded in myxoid stroma. Immunohistochemical staining showed that spindle cells and stellate cells were positive for vimentin, CD34 and BCL-2.

Conclusion DFML is a rare special variant of lipoma. It is benign, and it seems to be misdiagnosed as myxoid liposarcoma prior to the admission to our hospital. The pathological histomorphology and immunohistochemistry phenotypes are helpful to the diagnosis and differential diagnosis. Given that DFML mainly occurs in the elderly, this case is rare and worthy to be reported since it occurs in children.

Zusammenfassung

Ziel Untersuchung der pathologischen Merkmale und der Differenzialdiagnose eines dendritischen Fibromyxolipoms (DFML) in der Pädiatrie.

Methode Wir berichten über den Fall eines dendritischem Fibromyxolipoms im Rücken einer Patientin (6 Jahre alt), die am First Affiliated Hospital der Dalian Medical University diagnostiziert wurde. Das DFML wurde durch immunhisto-chemische Färbung von H&E und MaxVision untersucht. Für die Analyse der klinischen und pathologischen Merkmale wurde eine Literaturübersicht erstellt.

Ergebnisse Der Tumor war rund bis eiförmig und befand sich oberflächlich am Rücken der Patientin. Mikroskopisch bestand der Tumor hauptsächlich aus sternförmigen bis spindel-förmigen Zellen, seilartigen Kollagenfasern und einer unterschiedlichen Anzahl reifer Lipozyten, die in ein myxoides Stroma eingebettet waren. Immunhistochemische Färbungen zeigten, dass Spindelzellen und sternförmige Zellen positiv für Vimentin, CD34 und BCL-2 waren.

Schlussfolgerung Das DFML ist eine seltene, spezielle Variante des Lipoms. Es ist gutartig, und war anscheinend vor der Aufnahme in unsere Klinik als myxoides Liposarkom fehldiagnostiziert worden. Die pathologisch-histomorphologischen und immunhistochemischen Phänotypen sind für die Diagnose und Differenzialdiagnose hilfreich. Da ein DFML hauptsächlich bei älteren Menschen auftritt, ist dieser Fall einer 6-jährigen Patientin selten und berichtenswert.

Key words

Dendritic fibromyxolipoma - immunohistochemistry - clinicopathological features - pathology

Schlüsselwörter

Dendritisches Fibromyxolipom - Immunhistochemie - klinisch-pathologische Merkmale - Pathologie


Publication History

Article published online:
11 September 2020

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