GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity

Nektarios Barabutis; Mohammad S. Akhter; Mohammad A. Uddin; Khadeja-Tul Kubra; Andrew V. Schally

doi:10.1055/a-1149-9347

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2020; 52(05): 336-339
DOI: 10.1055/a-1149-9347

Endocrine Research

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity

Nektarios Barabutis

¹School of Basic Pharmaceutical and Toxicological Sciences, University of Louisiana Monroe, Monroe, LA, USA

,

Mohammad S. Akhter

¹School of Basic Pharmaceutical and Toxicological Sciences, University of Louisiana Monroe, Monroe, LA, USA

,

Mohammad A. Uddin

¹School of Basic Pharmaceutical and Toxicological Sciences, University of Louisiana Monroe, Monroe, LA, USA

,

Khadeja-Tul Kubra

¹School of Basic Pharmaceutical and Toxicological Sciences, University of Louisiana Monroe, Monroe, LA, USA

,

Andrew V. Schally

²Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, University of Miami, Miami, FL, USA

› Author Affiliations

Abstract

Growth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Our observations suggest that MIA-602 protects against the H₂O₂-induced breakdown of the brain endothelium and enhances its integrity by inducing P53, deactivating cofilin, and suppressing the RhoA inflammatory pathway. Thus, GHRH antagonists may offer an exciting possibility for the treatment of pathologies related to the blood brain barrier dysfunction, including the Parkinson’s and Alzheimer’s diseases.

Key words

P53 - inflammation - growth hormone

Full Text

References

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