Not all lesions are created equal: removal of a cavernous hemangioma

A 63-year-old woman was referred for evaluation of a subepithelial esophageal mass and dysphagia. Endoscopy at an outside hospital reported an increase in the size of the mass. Endoscopic ultrasound showed a hypoechoic well-defined subepithelial mass originating within the submucosa and measuring 23 mm in maximum diameter. Fine-needle aspiration of the mass was nondiagnostic. Owing to the dysphagia and the increase in size, we proceeded with endoscopic resection ([Video 1]).

Video 1 Endoscopic submucosal dissection with complete en bloc removal of an esophageal cavernous hemangioma.

The patient was placed in the supine position and the procedure was performed under general anesthesia. A GIF-HQ190 endoscope (Olympus Corp., Center Valley, Pennsylvania, USA) fitted with a transparent cap was advanced and identified a subepithelial mass in the mid esophagus, extending 20 cm to 24 cm from the incisors ([Fig. 1 a]). A submucosal injection of 0.9 % saline and methylene blue was made approximately 2 cm proximal to the lesion. A hybrid multipurpose T-knife (Erbe, Marietta, Georgia, USA) was used to make a 1.5-cm mucosal incision to create an entry point to the submucosal space. The submucosal layer was visualized with blue hue and further injected. The lateral margins were then carefully dissected with an insulated-tip knife IT2 (Olympus Corp.), in a proximal to distal direction. Using the pocket technique, dissection of the submucosal space was performed to expand the tunnel down to the distal end of the esophageal mass (settings: endocut Q current effect 3, interval 1, period 1, soft coag effect 2) ([Fig. 1 b]). Any visible vessels or bleeding were treated by coagulation using the hybrid knife or coagulation graspers. The lesion was then completely removed en bloc ([Fig. 1 c, d]). The defect was closed using a 2.0 polypropylene suture in a running suture pattern from the distal to the proximal end of the lesion. A cinching device was then used to cinch the suture. Finally, Duraclips (ConMed Corp., Utica New York, USA) were used to reinforce closure of the proximal defect.

Fig. 1 Endoscopic images. a The esophageal subepithelial lesion. b The submucosal tunnel after dissection. c The subepithelial lesion after complete en bloc resection. d The subepithelial lesion after retrieval, measuring 4 cm.

Low-power microscopic examination showed benign squamous mucosa with a submucosal-based benign vascular proliferation. Higher-power examination revealed large cystically dilated vessels with thin, focally fibrotic walls and a benign, flattened, endothelial lining, which was consistent with cavernous hemangioma ([Fig. 2]).

Fig. 2 The low-power examination (top row) showed benign squamous mucosa with a submucosal-based benign vascular proliferation. Higher-power examination (lower row) showed large cystically dilated vessels with thin, focally fibrotic walls and a benign, flattened, endothelial lining.

Barium swallow study showed no leak and the patient tolerated a regular diet. She was discharged home in a good condition and was completely asymptomatic at 1 month follow-up.

Cavernous hemangioma in the esophagus is a rare benign tumor. Small lesions are usually asymptomatic, but large tumors can often cause dysphagia. Histopathological examination establishes a definitive diagnosis, as radiographic and endoscopic features are inconclusive, accentuating the importance of a multidisciplinary therapeutic approach [1] [2]. Complete en bloc removal can be successfully achieved using endoscopic submucosal dissection, with resolution of symptoms.

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Competing interests

Dr. Sharaiha is a consultant for Boston Scientific, Olympus, Apollo, Cook Endoscopy and Medtronic.

• References

• 1 Imenpour H, Muti M, Pastorino G. Oesophageal cavernous haemangioma. Pathologica 2018; 110: 72-74
• 2 Santamaria-Barria JA, Banki F, Rajendran S. et al. Hemangioma of the cervical esophagus: a rare case of dysphagia mimicking a large esophageal polyp on endoscopy. J Thorac Cardiovasc Surg 2016; 152: e59-61