Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Stergios A. Polyzos; Jannis Kountouras; Maria Mavrouli; Panagiotis Katsinelos; Michael Doulberis; Elpida Gavana; Leonidas Duntas

doi:10.1055/a-0811-9136

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2019; 127(09): 598-602
DOI: 10.1055/a-0811-9136

Article

Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease

Stergios A. Polyzos

¹First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

,

Jannis Kountouras

²Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece

,

Maria Mavrouli

³Department of Microbiology, National Kapodestrian University, Athens, Greece

,

Panagiotis Katsinelos

²Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece

,

Michael Doulberis

⁴Department of Internal Medicine, University Hospital Inselspital, Bern, Switzerland

,

Elpida Gavana

¹First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

,

Leonidas Duntas

⁵Endocrine Unit, Evgenidion Hospital, National Kapodestrian University, Athens, Greece

› Author Affiliations

Abstract

Objective Main aim of this study was to evaluate circulating selenoprotein P (SEPP) levels in patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) compared with healthy controls.

Methods Thirty-one patients with biopsy-proven NAFLD (15 with SS, 10 with borderline NASH, 6 with definite NASH) and 27 matched controls without NAFLD were enrolled. Serum SEPP levels and liver function tests plus biochemical parameters were measured with ELISA and standard methods, respectively. Homeostatic model of assessment - insulin resistance (HOMA-IR) was calculated.

Results SEPP levels were statistically different between groups (p-value for trend=0.043). In pairwise comparisons, SEPP was lower in definite NASH compared with controls (p=0.029), but not SS (p=0.18) or borderline NASH (p=0.35). SEPP was not different between controls, SS and borderline NASH. The unadjusted trend between the controls, SS and NASH patients remained essentially unchanged after adjustment for age, sex, log(ALT) and waist circumference, but it marginally lost significance when log(HOMA-IR) entered into the model. SEPP levels were not different between groups of different severity of steatosis, fibrosis, hepatocellular ballooning, lobular and portal inflammation.

Conclusions Lower SEPP levels were observed in patients with definite NASH compared with controls, a finding warranting larger studies.

Key words

inflammation - nonalcoholic fatty liver disease - nonalcoholic steatohepatitis - noninvasive index - selenium - selenoprotein P

Full Text

References

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