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Planta Med 2018; 84(17): 1249-1254
DOI: 10.1055/a-0634-6597
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Blood Pressure and Cognitive Performance After a Single Administration of a Camphor-Crataegus Combination in Adolescents with Low Blood Pressure

Rainer Schandry
1   Psychology Department, Ludwig-Maximilians-Universität, Munich, Germany
,
Daniela Lindauer
2   Ludwig-Maximilians-Universitaet, Munich, Germany
,
Matthias Mauz
3   Robugen GmbH, Pharmazeutische Fabrik, Esslingen, Germany
› Author Affiliations
Further Information

Publication History

received 24 November 2017
revised 15 May 2018

accepted 22 May 2018

Publication Date:
18 June 2018 (online)

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Abstract

Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 – 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking. Blood pressure and heart rate were assessed during a rest period, prior to substance administration, 1 min thereafter, and after about 5 min. Additionally, performance was assessed by two cognitive tests. After administration of CCC, a significantly greater rise in blood pressure occurred compared to placebo. In the cognitive tasks, no significant differences were observed. No adverse events or subjective complaints were reported at the final examination; thus, the present study provides evidence for the safety and tolerability of CCC after a single administration.

Key words

blood pressure - hypotension - D-camphor - Crataegus laevigata - Crataegus monogyna - Rosaceae - RCT Phase 3 - cognition

Supporting Information

    Tables 1S and 2S display separately for study 1 and study 2 the means and standard deviations for systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate before and after substance administration.

  • Supporting Information
 

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