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Drug Res (Stuttg) 2018; 68(11): 631-636
DOI: 10.1055/a-0620-8210
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Diabetic Potential of Murraya Koenigii (L.) and its Antioxidant Capacity in Nicotinamide-Streptozotocin Induced Diabetic Rats

Fauzul Husna
1   Doctoral Programme in Biomedical Sciences Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
2   Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Aceh, Indonesia
,
Franciscus D. Suyatna
3   Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
,
Wawaimuli Arozal
3   Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
,
Erni H. Poerwaningsih
4   Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
› Author Affiliations
Further Information

Publication History

received 25 August 2017

accepted 09 October 2017

Publication Date:
25 May 2018 (online)

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Abstract

Aim and Objective The present study aims to investigate whether the antihyperglycemic effect of Murraya koenigii is mediated by antioxidant properties and insulin mimetic effect.

Methods Thirty Spraque-Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The STZ-NA diabetic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w). After the administration of Murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Blood and organ samples were collected under a fasting condition. The body weight and blood glucose levels were measured. Hepatic enzymes were determined using a commercial kit, protein levels were estimated by Bradford’s method, and plasma insulin was assayed by an ELISA kit. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated by the TBA-Wills method and Ellman’s method, respectively.

Results Ethanolic extract of Murraya koenigii showed a significant reduction in blood glucose level at both doses, 200 and 400 mg/kg b.w. In addition, Murraya koenigii exhibited a profound antioxidant effect with decreased MDA level and increased GSH level, particularly at the 200 mg/kg b.w. and significantly decreased the HOMA-IR index.

Conclusions The present study reveals that Murraya koenigii possesses antidiabetic activity and antioxidant effects on STZ-NA induced diabetes mellitus.

Key words

Diabetes - Murraya koenigii - oxidative stress - streptozotocin-nicotinamide
 

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