Homeopathy 2005; 94(04): 233-240
DOI: 10.1016/j.homp.2005.08.019
Original Paper
Copyright ©The Faculty of Homeopathy 2005

Harm in homeopathy: Aggravations, adverse drug events or medication errors?

C Endrizzi
1   Homeopathic Clinic, Reference Regional Centre, Campo di Marte Hospital, AUSL 2 Lucca, Italy
,
E Rossi
1   Homeopathic Clinic, Reference Regional Centre, Campo di Marte Hospital, AUSL 2 Lucca, Italy
,
L Crudeli
2   Pharmaceutical Department of Health Services, AUSL 2 Lucca, Italy
,
D Garibaldi
2   Pharmaceutical Department of Health Services, AUSL 2 Lucca, Italy
› Author Affiliations
Further Information

Publication History

Received03 December 2004
revised01 July 2005

accepted15 August 2005

Publication Date:
29 December 2017 (online)

Abstract

Background The assessment of harm arising from the use of homeopathic medicine is much discussed, but there is little published data on the subject.

Aim To study prospectively adverse drug events related to homeopathic medicines.

Setting The data were gathered between 1 June 2003 and 30 June 2004 during follow-up visits consecutively carried out at the Homeopathic Clinic, Campo di Marte Hospital, Azienda USL 2, Lucca (Italy). They refer to effects following the administration of a homeopathic medicine, prescribed according to the classical homeopathic method.

Methods Reports collected by a homeopathic doctor (not the prescribing doctor) on the nature and intensity of the effect, dose and frequency of administration, time relationship between the drug use and the adverse events, challenge, unchallange possible concomitant factors, causality (improbable, unlikely, possible, probable, certain).

Results Out of 335 homeopathic consecutive follow-up visits between 1 June 2003 and 30 June 2004, nine adverse reactions were reported (2.68%) including one case of allergy to lactose, excipient of the granules.

Conclusions Adverse events to homeopathic drugs exist and are distinguishable from homeopathic aggravations, but are rare and not severe.

 
  • References

  • 1 Linde K.. et al. Are the clinical effects of homoeopathy placebo effects?. Lancet 1997; 350: 834-843.
  • 2 Vickers AJ, Smith C. Homeopathic Oscillococcinum for preventing and treating influenza and influenza-like syndromes. Cochrane Library 2001;1–10.
  • 3 Cucherat M., Haugh M.C., Gooch M.. et al. Evidence of clinical efficacy of homeopathy. A meta-analysis of clinical trials. Homeopathic Medicine Research Advisory Group. Eur J Clin Pharmacol 2000; 56: 27-33.
  • 4 Ernst E.. A systematic review of systematic reviews of homeopathy. Br J Clin Pharm 2002; 54 (06) 577.
  • 5 Ernst E. Complementary medicine: where is a evidence? J Fam Pract 2003;52(8).
  • 6 Vandenbroucke J.P., de Craen A.J.M.. Alternative medicine: a «mirror image» for scientific reasoning in conventional medicine. Ann Intern Med 2001; 135 (07) 507-513.
  • 7 Ernst E.. Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organ 2000; 78 (02) 252-257 PUBMED abstract
  • 8 ISTAT. Indagine multiscopo sulle famiglie ‘Condizioni di salute e ricorso ai servizi sanitari’, ISTAT 1999–2000.
  • 9 Giannelli M., Cuttini M., Arniani S., Baldi P., Buiatti E.. Non-conventional medicine in Tuscany: attitudes and use in the population. Epidemiol Prev 2004; 28 (01) 27-33.
  • 10 Fisher P.. Aims and priorities for research in complementary medicine: a proposal for an adverse effect reporting schema. Compl Med Res 1987; 1: 35-44.
  • 11 Benmeir P., Neuman A., Weinberg A.. et al. Giant melanoma of the inner thigh: a homeopathic life-threatening negligence. Ann Plan Surg 1991; 27: 583-585.
  • 12 Kerr H.D.. Pancreatitis following ingestion of a homeopathic preparation. N Engl J Med 1986; 314: 1642-1643.
  • 13 Aberer W., Strohal R.. Homeopathic preparations-severe adverse effects, unproven benefits. Dermatologica 1991; 182 (04) 253
  • 14 Chakraborti D., Mukherjee S.C., Saha K.C.. et al. Arsenic toxicity from homeopathic treatment. J Toxicol Clin Toxicol 2003; 41 (07) 963-967.
  • 15 Helbling A., Brander K.A., Pichler W.J.. et al. Anaphylactic shock after subcutaneous injection of mandragora D3 homeopathic drug. J Allergy Clin Immunol Online 2000; 1 (05) 989-990.
  • 16 Varma P.N.. Side Effect & Adverse Symptoms of Homeopathic Medicine in their Lower Attenuation. New Delhi: Jain Publisher; 2001
  • 17 Dantas F., Rampes H.. Do homoeopathic medicine provoke adverse effects? A systematic review. Br Hom J 2000; 89 (01) 35-38.
  • 18 Schmidt K., Ernst E.. Aspect of MMR. Survey shows that some homeopaths and chiropractors advise against MMR. BMJ 2002; 325: 597
  • 19 Galatti L., Caputi A. P. Un nuovo sistema di classificazione delle ADR? www.farmacovigilanza.org .
  • 20 Caputi A. Classificazione e definizioni delle ADRs. www.farmacovigilanza.org .
  • 21 Ioannidis J., Evans S., Gotzsche P.. et al. Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann. Intern Med. 2004; 141: 781-788.
  • 22 EMEA Status. Guideline for Good Clinical Practice (GPC). CPMP/ICH/135/95.
  • 23 Nebeker J., Barach P., Samore M.. Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting. Ann Intern Med. 2004; 140: 795-801.
  • 24 Scheda farmacovigilanza per fitoterapia e integratori alimentari. www.ministerosalute.it .
  • 25 Allegato 7 (scheda per la valutazione della gravità degli eventi avversi e del grado di correlazione con la terapia) www.ministerosalute.it .
  • 26 Hahnemann SCF Organon of Medicine VI ed New Delhi: B. Jain Publishers, Pvt, Ldt., 1982, p. 290.
  • 27 De Schepper L.. LM potencies: one of the hidden treasures of the sixth edition of the Organon. Br Hom J 1999; 88: 128-134.
  • 28 Rezzani C M WinChip: computerised homeopathic investigation program: a data collection tool to help the doctor in daily practice and a real instrument to prove and improve homeopathy. Proceedings of the International Conference ‘Improving the success of homeopathy 2. developing and demonstrating effectiveness’ London, 15–16 April 1999, p 32.
  • 29 Kent JT. Lectures on Homeopathic Philosophy, vol 35. New Delhi: B. Jain Publisher, Pvt, Ldt., 1981, p 253.
  • 30 Bellavite P.. Complexity science and homeopathy: a synthetic overview. Homeopathy 2003; 92 (04) 203-212.
  • 31 Schwartz G.E., Russek L.G., Bell I.R.. et al. Plausibility of homeopathy and conventional chemical therapy: the systemic memory resonance hypothesis. Med Hypotheses 2000; 54 (04) 634-637.
  • 32 Anelli M., Scheepers L., Sermeus G., Van Wassenhoven M.. Homeopathy and health related quality of life: a survey in six European contries. Homeopathy 2002; 91: 18-21.
  • 33 Riley D., Fischer M., Singh B., Haidvogl M., Heger M.J.. Homeopathy and conventional medicine: an outcomes study comparing effectiveness in a primary care setting. J Altern Complement Med 2001; 7 (02) 149-159.
  • 34 Endrizzi C, Rossi E, Leone C, Patient therapy compliance at Asl district 2 Homoeopathic Clinic, Lucca. Convegno AMIAR, Torino 9 aprile 2005.
  • 35 Endrizzi C, Rossi E, Crudeli L, Garibaldi D, Farmacovigilanza in ambito omeopatico. Costi e benefici della terapia omeopatica in ambito pubblico Lucca 16-11-2004, Atti del Convegno.
  • 36 Pomposelli R., Codecà G., Bergonzi R., Andreoni C., Salvi G.P., Costini G., Piasere V., Bellavite P.. Terapia omeopatica in pazienti con patologia artroreumatica. Med Nat (Milano) 2003; 13 (06) 44-50.
  • 37 Grabia S., Ernst E.. Homoeopathic aggravation: a systemic review of randomised, placebo-controlled clinical trials. Homeopathy 2003; 92: 92-98.
  • 38 Rossi E, Crudeli L, Garibaldi D. Valutazione delle variazioni del consumo farmacologico convenzionale e dei costi economici in corso di terapia omeopatica classica in pazienti affetti da disturbi delle vie respiratorie Proceedings of the International Conference ‘Safety evaluation of complementary and alternative medicine’, Palazzo delle Esposizioni, Empoli 24–25 October, 2003, p. 23.
  • 39 Galatti L, Caputi AP. Informazione ai pazienti sugli effetti collaterali dei farmaci e loro percezione da parte dei pazienti stessi. Da uno studio apparso su Lancet. www.farmacovigilanza.org .