Download PDF
Homeopathy 2004; 93(01): 12-16
DOI: 10.1016/j.homp.2003.10.003
Original Paper
Copyright ©The Faculty of Homeopathy 2003

Action of Causticum in inflammatory models

J de Araújo Prado Neto
1   Faculdade de Ciências da Saúde de São Paulo, Instituto Brasileiro de Estudos Homeopáticos, R. Bartolomeu de Gusmão, 86, CEP 04111-020, S. Paulo, SP, Brazil
,
F.F Perazzo
2   Laboratório de Fitofármacos, Universidade de Alfenas, Rod. MG 179, km 0, CP 23, CEP 37130-000, Alfenas, Minas Gerais, Brazil
,
L.G.V Cardoso
2   Laboratório de Fitofármacos, Universidade de Alfenas, Rod. MG 179, km 0, CP 23, CEP 37130-000, Alfenas, Minas Gerais, Brazil
,
L.V Bonamin
1   Faculdade de Ciências da Saúde de São Paulo, Instituto Brasileiro de Estudos Homeopáticos, R. Bartolomeu de Gusmão, 86, CEP 04111-020, S. Paulo, SP, Brazil
,
J.C.Tavares Carvalho
1   Faculdade de Ciências da Saúde de São Paulo, Instituto Brasileiro de Estudos Homeopáticos, R. Bartolomeu de Gusmão, 86, CEP 04111-020, S. Paulo, SP, Brazil
2   Laboratório de Fitofármacos, Universidade de Alfenas, Rod. MG 179, km 0, CP 23, CEP 37130-000, Alfenas, Minas Gerais, Brazil
› Author Affiliations
Further Information

Publication History

Received28 March 2003
revised03 June 2003

accepted22 October 2003

Publication Date:
22 December 2017 (online)

    Permissions and Reprints

Abstract

The anti-inflammatory effect of Causticum was evaluated using acute and chronic inflammatory models in vivo. The administration of concentrated Causticum solution into the hind paw of rats produced an inflammatory reaction with oedema formation within the first hour, showing that Causticum acts as an oedematogenic agent. Carrageenin induced rat paw oedema was significantly inhibited (P<0.05) in the group treated with Causticum 30cH solution compared to control. Groups treated with potentized Causticum (6cH, 12cH, 30cH and 200cH), showed significant inhibition (P<0.05) of the inflammation pre-induced by carrageenin. However pre-treatment with Causticum 30cH for 6 days (0.5 ml, daily) did not significantly inhibit granulation using an implantation method.

Keywords

Causticum - anti-inflammatory - in vivo - potencies
 

  • References

  • 1 Schwabe W. Pharmacopoeia Homoeopathica Polyglotta. Tradução portuguesa, Lisboa: Franscisco José da Costa, 1894, p 62.
    PubMed
  • 2 Charrette G. A Matéria Médica Prática. Tradução portuguesa: Murillo O. Paiva. Paraná: Artes Gráficas Mocelo, 1990, pp 110–114.
    PubMed
  • 3 Lathoud JA. Matéria Medica Homeopática. Buenos Aires: Editorial Albatros, 1989, p 250.
    PubMed
  • 4 Jahr GHG. Farmacopea Homeopatica. Madrid: Miraguano Ediciones, 1987, pp 75–77.
    PubMed
  • 5 Hahnemann S. The Chronic Diseases, their Peculiar Nature and their Homoeophathic Cure (translated from German; edition of 1835 by Tafel and Hughes). New Delhi: B. Jain Publishers 1993, pp 558–559.
    PubMed
  • 6 Dorta AAS. Dicionário de Medicamentos Homeopáticos. Santos Livraria Editora 1999, pp 656–657.
    PubMed
  • 7 Nash EB. Indicações caracterı́sticas de terapêutica homeopática. Rio de Janeiro: Gráfica Editora Arte Moderna Ltda, 1948, p 285.
    PubMed
  • 8 Phatak SR. Matéria Médica de Medicinas Homeopáticas. New Delhi: B. Jain Publishers, 1994, p 248.
    PubMed
  • 9 Farrington EA. Clinical Materia Medica. New Delhi: B. Jain Publishers, 1995, p 729.
    PubMed
  • 10 Vagner AF. Preparacion de lo Causticum. In: Martinez JA (ed). Pharmacompendium: Farmacopéia Homeopática. Buenos Aires: Albatros, 1983, pp 120–127.
    PubMed
  • 11 Boericke W. Manual de Matéria Médica Homeopática. Tradução portuguesa Álvaro Mesquita Júnior. São Paulo: Robe Editorial, 1997, pp 119–120.
    PubMed
  • 12 Carvalho JCT, Sertié JAA, Barbosa MVJ, et al. Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog. J Ethnopharm 1999; 64: 127–133.
    PubMed
  • 13 Niemegeers CJE, Awouters F, Lenaerts FM, Janssey AJ. The activity of suprofen on nystatin-induced paw oedema in rats. Arzneimittel- Forschung 1975; 23: 1516–1519.
    PubMed
  • 14 Swingle KF, Shideman FE. Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents. J Pharm Exp Ther 1972; 5: 226–234.
    PubMed
  • 15 Meier R, Schuler W, Desaullles P. Zur frage des mechanismus der hemmung des bindegewebswachstums durch cortisone. Experientia 1950; 6: 469–471.
    PubMed
  • 16 Van Arman CG, et al. Some details of the inflammation caused by yeast and carrageenan. J Pharm Exp Therap 1965; 150: 328–334.
    PubMed
  • 17 Gardner DL. Adjuvant induced arthritis in the rats. Ann Rheumatism Dis 1960; 19, P 369.
    PubMed
  • 18 Katsuhiko Y, Takashi M. Comparison of the anti-inflammatory effects of dexametasone, indometacin and 8W755 on carrageenin-induced pleurisy in rats. Eur J Pharmacol 1982; 77: 229–236.
    PubMed
  • 19 Vinegar R, Schreiber W, Hugo, R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp 1976; 166: 96–103.
    PubMed
  • 20 Guidugli-Neto J. Elementos de Patologia Geral. São Paulo: Santos, 1997, pp 102–115.
    PubMed