hämostaseologie
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Sachkov, A.
New Oral Anticoagulants for Prevention of Complications of Venous Thromboembolism in Burn Patients
Sachs, U.J.
Successful Control of Bleeding with Emicizumab in Aquired Haemophilia A: A Case Report
Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT): Evidence that Placental rather than Systemic Inflammation is a Modulator of Disease Severity
Direct Oral Anticoagulants in Patients with Antiphospholipid Syndrome: Results from a Retrospective Study in a Real-life Patient Cohort
Anti-Glycoprotein V Autoantibodies in Patients with Immune Thrombocytopenia
Direct Oral Anticoagulants in Patients with Antiphospholipid Syndrome: Results from a Retrospective Study in a Real-life Patient Cohort
Safronenko, A.
The Assessment of the Frequency of Complications in the Analysis of the Time Interval between Anticoagulants and Haemostatic Drugs among Patients after the Total Knee and Hip Replacement
Sahu, I.
Phosphate-induced ORAI1 Expression and Store Operated Ca
2+
Entry in Megakaryocytes
Salazar-Chacon, C.
Hereditary Haemorrhagic Telangiectasia (HHT) as an Important Rare Haemorrhagic Disorder in Costa Rica - Report of Costa Rica
Salazar-Sanchez, L.
Hereditary Haemorrhagic Telangiectasia (HHT) as an Important Rare Haemorrhagic Disorder in Costa Rica - Report of Costa Rica
Samasca, G.
Determination of Age Dependent Reference Ranges for PT and aPTT
Sangalli-Baruffaldi, J.
A Universal Anti-Xa Assay for the Determination of Rivaroxaban and Apixaban Plasma Concentrations: An In vitro Investigation and Evaluation Study in Real-life Clinical Practice
Santagostino, E.
Long-term Safety and Efficacy of rIX-FP in Patients with Hemophilia B: Intermediate Results from a Phase IIIb Extension Study
Population Pharmacokinetic Analysis of Recombinant Fusion Protein Linking Coagulation Factor IX with Recombinant Albumin (rIX-FP) in Adult and Pediatric Patients with Severe Hemophilia B
Systematic Review of Efficacy of Recombinant Factor IX Products for Prophylactic Treatment of Hemophilia B
Sapkota, A.
Metabolome Analysis for New Possible Hemostasis Biomarkers
Sargent, N.
Fibrinogen Concentrate vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study
Schäffer, T.E.
Platelet Lipidome and Lipid Induced Thromboinflammatory Actions are Influenced by the CXCL12-CXCR4-CXCR7 Axis
Platelet Lipidome and Lipid Induced Thromboinflammatory Actions are Influenced by the CXCL12-CXCR4-CXCR7 Axis
Schaller, M.
Anti-ADAMTS13 Autoantibody-specific Anti-idiotypic Antibodies Restore ADAMTS13 Activity in Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) Patients
Anti-ADAMTS13 Autoantibody-specific Anti-idiotypic Antibodies Restore ADAMTS13 Activity in Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) Patients
Scharrer, I.
Eleven Relapses in a Cohort of 78 Patients with Immune Thrombotic Thrombocytopenic Purpura (iTTP): Data from the German TTP-Registry
Scheinost, M.
Plasmin-induced Alterations to Platelet GPIIb/IIIa Receptors Impair Secondary Blood Clot Firmness
Schellong, S.
Management of Venous Thromboembolism in Routine Clinical Practice - Results from the Global GARFIELD-VTE Registry
Schellongowski, P.
Emicizumab for the Treatment of Acquired Hemophilia A: Lessons Learned from 4 very Different Cases
Schilling, K.
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Schinzel, H.
Cost-effectiveness of a Telemedicine-based Coagulation Service versus Routine Medical Care for the Management of Patients Receiving Vitamin K-antagonists - Results from the thrombEVAL Study
Schlagenhauf, A.
Elevated Bile Acid Levels Induce Tissue Factor Activity in Hepatocytes
Schlensak, C.
Acquired von Willebrand Syndrome during Mechanical Circulatory Support and Extracorporeal Membrane Oxygenation: Rapid Onset and the Demand for Point of Care Testing
Schmidt, A.
Responsiveness of PBMCs Isolated from Healthy Individuals towards rFVIII and rFVIIIFc
Identification of Plasma Cytokine Levels Correlating with FVIII Inhibitor Titer during ITI
Affinities of FVIII-specific IgG1 and IgG4 during ITI
Schmidt, F.P.
Treatment of High-risk Pregnancies with Tinzaparin
Schmidt, F.-P.
Protein z Deficiency in Risk Pregnant Women
Schmidt, G.J.
Altered Protein Profiles in Platelets of Lupus Anticoagulant Positive Patients - New Players in LA-related Thrombosis?
Schmidt, T.
Bone Mineral Density and Bone Microstructure in Patients with Haemophilia in Northern Germany: Preliminary Findings of a Single Centre Study
Schmidtmann, I.
Eleven Relapses in a Cohort of 78 Patients with Immune Thrombotic Thrombocytopenic Purpura (iTTP): Data from the German TTP-Registry
Schmitt, C.
Emicizumab Prophylaxis Administered Once-weekly or Every Two Weeks Provides Effective Bleed Prevention in Persons with Hemophilia A (PwHA) without Inhibitors - Results from the Phase III HAVEN 3 Study
Emicizumab Prophylaxis Administered Once-weekly or Every Two Weeks Provides Effective Bleed Prevention in Persons with Hemophilia A (PwHA) without Inhibitors - Results from the Phase III HAVEN 3 Study
Schmitz, K.
FibrinoQuick - A Rapid Fibrinogen Assay for Patient Blood Management
Schmoldt, B.
Smart Medication™ ITP - Feasibility of Online Surveillance in Patients with Immunthrombocytopenia
Schmoldt, D.
Smart medication
tm
- A Pilot Study for Investigating the Feasibility of Speech Recognition of Natural Language to Access Electronic Patient Diary
Impact of GDPR (DSGVO) on Smart Medication™ Electronic Patient Diary
Schneider, A.
The Relation between Coagulant and Vascular Function in Adult Survivors of Childhood Cancer
Schneider, S.W.
The Endothelial Glycocalyx Contributes to the Anchorage of von Willebrand Factor Fibers to the Vascular Endothelium
Increased Permeability of Tumor Blood Vessels is Triggered by Membrane Attack Complex Activated Neutrophils
Platelet-derived von Willebrand Factor Fosters Intracranial Hypercoagulation in Metastatic Brains of Mice and Humans
Schneppenheim, R.
Investigation of VWD Type 2B Variants by Light Transmission Aggregometry
More severe ADAMTS13 Deficiency in Homozygous versus Compound Heterozygous Carriers of the ADAMTS13 c.4143_4144dupA Mutation in Congenital Thrombotic Thrombocytopenic Purpura (cTTP): Impact on Disease Onset?
Schober, S.
Congenital Antithrombin Deficiency Type II: A Case Report
Schöchl, H.
Plasmin-induced Alterations to Platelet GPIIb/IIIa Receptors Impair Secondary Blood Clot Firmness
Modified ROTEM
®
xxtem Clotting Time Shows better Correlation with Endogenous Thrombin Potential than Standard Extem
Schoenichen, C.
The Inflammatory Landscape during Myocardial Reperfusion Injury Depends on Distinct Neutrophil Phenotypes
Scholz, C.W.
GECAT - German Evaluation of Cancer associated Thrombosis: A Prospective Register Trial for Patients with Active Cancer and Venous Thromboembolism in Berlin
Scholz, U.
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Baseline Data from a 24-month Prospective, Non-interventional, Multicentre Study in Germany to Evaluate the Real-world Usage and Effectiveness of rFVIIIFc and rFIXFc in Patients with Haemophilia A or B (PREVENT)
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Measurement of Thrombophilic Profile under Removing DOACs from Plasma Samples
Haemophilia A Prophylaxis with FVIII in Real-life: Snapshot Analysis on the Observational Study “Prevention of Bleeding in Haemophilia A by Prophylactic Treatment with Octanate
®
, Wilate
®
or Nuwiq
®
- NIS Previq”
Schönermarck, U.
Incidence of Acquired Thrombotic Thrombocytopenic Purpura Episodes in adults in Germany: Results of a Hospital Level Study and Projection to National Estimates
Schönichen, C.
Platelet Serotonin in Arterial and Deep Vein Thrombosis
Schreiner, R.
Study Design for Evaluating an In Vitrodiagnostic Test for Direct Oral Anticoagulants
Schrezenmeier, H.
Results from a Phase 3, Multicenter, Noninferiority Study of Ravulizumab (ALXN1210) versus Eculizumab (ECU) in Adult Patients (pts) with Paroxysmal Nocturnal Hemoglubinuria (PNH) Naive to Complement Inhibitors (CI)
Schrotz-King, P.
Plasma Levels of Soluble CLEC-2 in Patients with Different Solid Tumors
Schulze, H.
Use of Targeted High-throughput Sequencing for Genetic Classification of Patients with Bleeding Diathesis and Suspected Platelet Disorder
Use of Targeted High-throughput Sequencing for Genetic Classification of Patients with Bleeding Diathesis and Suspected Platelet Disorder
Schurr, Y.
Platelet Lamellipodia Formation is not Required for Thrombus Formation and Stability
Platelet Lamellipodia Formation is not Required for Thrombus Formation and Stability
Schüssel, P.
Acquired von Willebrand Syndrome during Mechanical Circulatory Support and Extracorporeal Membrane Oxygenation: Rapid Onset and the Demand for Point of Care Testing
Schutgens, R.
Safety and Efficacy of Turoctocog Alfa in Severe and Moderately Severe Previously Treated Patients with Haemophilia A: Interim Results after >4,000 Exposure Days (Guardian 5)
Schwabe, D.
Identification of Plasma Cytokine Levels Correlating with FVIII Inhibitor Titer during ITI
Schwabl, P.
Intraperitoneal Activation of Blood Coagulation via Tissue Factor Exposing Extracellular Vesicles in Patients with Liver Disease and Ascites
Schwander, B.
Incidence of Acquired Thrombotic Thrombocytopenic Purpura Episodes in adults in Germany: Results of a Hospital Level Study and Projection to National Estimates
Schwartz, B.
Efficacy and Safety of Fibrinogen Concentrate for On-demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency - A Phase 3 Study
Scully, M.
Safety Results Normalized to Time of Exposure during the Phase 3 HERCULES Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura
Risk Factors and Manageability of the Mucocutaneous Bleeding Profile Observed in aTTP Patients Treated with Caplacizumab during the Phase III HERCULES Study
Safety Results Normalized to Time of Exposure during the Phase 3 HERCULES Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura
Seeger, S.
Interim Results of a Non-interventional Study on Efficacy and Tolerability of a VWF/FVIII Concentrate in von Willebrand's Disease
Haemophilia A Prophylaxis with FVIII in Real-life: Snapshot Analysis on the Observational Study “Prevention of Bleeding in Haemophilia A by Prophylactic Treatment with Octanate
®
, Wilate
®
or Nuwiq
®
- NIS Previq”
Seibert, F.
Incidence of Acquired Thrombotic Thrombocytopenic Purpura Episodes in adults in Germany: Results of a Hospital Level Study and Projection to National Estimates
Seidel, M.
Diagnosis of ETV6-mutation Related Thrombocytopenia by Immunofluorescence Microscopy
Seifert, W.
Long-term Safety and Efficacy of rIX-FP in Patients with Hemophilia B: Intermediate Results from a Phase IIIb Extension Study
Population Pharmacokinetic Analysis of Recombinant Fusion Protein Linking Coagulation Factor IX with Recombinant Albumin (rIX-FP) in Adult and Pediatric Patients with Severe Hemophilia B
Seifried, E.
In vitro and In vivo Validation of a Laboratory Assay for Monitoring Survival of Transfused Platelets: Tracking HLA Mismatch between Donor and Recipient
Selbitz, A.
Thrombocytopenia Related to Defects in Platelet Cytoskeleton Regulation Genes
Seneres, A.
Successful Therapeutic Management and Delivery in a Pregnancy Complicated by Secondary Evans Syndrome from Systemic Lupus Erythematosus and Concurrent Antiphospholipid Syndrome
Severin, K.
Comparison of Electronic Documentation with Smart Medication
tm
between 2014 and 2017
Treatment Pattern and Pain Related to Joint Bleeds and Non-joint Bleeds - real Life Data According to Electronic Diary Smart-medication
TM
Shafner, L.
Results from a Phase 3, Multicenter, Noninferiority Study of Ravulizumab (ALXN1210) versus Eculizumab (ECU) in Adult Patients (pts) with Paroxysmal Nocturnal Hemoglubinuria (PNH) Naive to Complement Inhibitors (CI)
Shahidi, N. Hamedani
Monitoring of Emicizumab using a Two-stage chromogenic tenase platform: assay Development and Validation
Shahidi-Hamedani, N.
Development and Validation of a Novel Flow Cytometric Assay for Quantification of Plasma ADAMTS-13 Activity (AD13a-FCA)
Shima, M.
Emicizumab Prophylaxis Administered Once-weekly or Every Two Weeks Provides Effective Bleed Prevention in Persons with Hemophilia A (PwHA) without Inhibitors - Results from the Phase III HAVEN 3 Study
Emicizumab Prophylaxis Administered Once-weekly or Every Two Weeks Provides Effective Bleed Prevention in Persons with Hemophilia A (PwHA) without Inhibitors - Results from the Phase III HAVEN 3 Study
Sicre de Fontbrune, F.
Results from a Phase 3, Multicenter, Noninferiority Study of Ravulizumab (ALXN1210) versus Eculizumab (ECU) in Adult Patients (pts) with Paroxysmal Nocturnal Hemoglubinuria (PNH) Naive to Complement Inhibitors (CI)
Sidhu, J.
Population Pharmacokinetic Analysis of Recombinant Fusion Protein Linking Coagulation Factor IX with Recombinant Albumin (rIX-FP) in Adult and Pediatric Patients with Severe Hemophilia B
Siebert, M.
Development of an Adherence Questionnaire for Haemophilia Patients of the German Health System
Assessment of Joint Health in Children with Haemophilia - Results of the German Energy Study
Sievers, B.
LPS-induced Expression of Monocyte Tissue Factor (TF) Antigen Correlates with Markers of Systemic Inflammation in Patients with Hemophilia A and B
Myeloperoxidase (MPO) Inhibits the Procoagulant Activity (PCA) of Extracellular DNA
Sigl-Kraetzig, M.
Systematic Comparison of MRI and ultrasound scores to Assess Arthropathy in Children and Adolescents with Hemophilia
Vaccination in Patients with Hemophilia - Results from an Online Survey among German Haemostaseologists
Singer, H.
Derivation of Patient Specific iPSCs and iHEP Cell Lines as a Tool to Investigate VKCFD2 in a Native Cellular Environment
F8 Heavy vs Light Chain Located Pre-terminal Stop Codon (PTC): Comparing the Intracellular Fate of Endogenous FVIII Variants in IPS Derived Endothelial Cells
Singh, S.
Calcium Binding to FXIII-A Subunit: Unique Characteristics
The FXIIIA
2
B
2
Heterotetrameric Complex Structure: Unequal Pairing within a Symmetric Complex
Sinkovec, H.
Risk and Determinants of Provoked Recurrent Venous Thromboembolism: A Prospective Cohort Study
Sinn, M.
GECAT - German Evaluation of Cancer associated Thrombosis: A Prospective Register Trial for Patients with Active Cancer and Venous Thromboembolism in Berlin
Sirb, H.
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Changes in Hemophilia Treatment in Eastern Germany in the Last Decade - A Survey from the Kompetenznetz Hämorrhagische Diathese Ost (KHDO)
Slavik, L.
The Comparison of Manual and Automatic Interference Determination on Coagulometers ACL Top 750 CTS and Roche Cobas t511 for Routine Coagulation Tests
Slonka, J.
Successful Control of Bleeding with Emicizumab in Aquired Haemophilia A: A Case Report
Smith, G.
Effects of WSCM, eVCM and Nicotine on monocyte adhesion to human aortic endothelial cells
Soliman, A.
In Silico Analysis of Single Nucleotide Polymorphism in Human Prothrombin Gene
Sollfrank, S.
Severe Thrombocytopenia and Platelet Granule Dysfunction Associated with the Combination of Novel Heterozygous Variants in TUBB1 and ITGB3
Detection and Differential Diagnosis of Prekallikrein Deficiency: Genetic Study of New Families and Systematic Review of the Literature
Solomon, C.
Efficacy and Safety of Fibrinogen Concentrate for On-demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency - A Phase 3 Study
Fibrinogen Concentrate vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study
Sopivnik, I.
Quality of Plasma Collected with Closed Plasmapheresis Disposables
Sousa, R.
Safety Results Normalized to Time of Exposure during the Phase 3 HERCULES Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura
Risk Factors and Manageability of the Mucocutaneous Bleeding Profile Observed in aTTP Patients Treated with Caplacizumab during the Phase III HERCULES Study
Safety Results Normalized to Time of Exposure during the Phase 3 HERCULES Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura
Incidence of Acquired Thrombotic Thrombocytopenic Purpura Episodes in adults in Germany: Results of a Hospital Level Study and Projection to National Estimates
Spannagl, M.
Emicizumab and its Impact on aPTT-based Assays and FVIII Inhibitor Measurement
Functional Characterisation of a von Willebrand Factor Concentrate with Low Factor VIII Content - Multimeric and Flow Chamber Analysis and a Case Report
Spannnagl, M.
Monitoring of Emicizumab and Factor VIII Concentrate Interaction
Späth-Schwalbe, E.
GECAT - German Evaluation of Cancer associated Thrombosis: A Prospective Register Trial for Patients with Active Cancer and Venous Thromboembolism in Berlin
Sperr, A.
Platelet Lamellipodia Formation is not Required for Thrombus Formation and Stability
Platelet Lamellipodia Formation is not Required for Thrombus Formation and Stability
Sperr, W.
Emicizumab for the Treatment of Acquired Hemophilia A: Lessons Learned from 4 very Different Cases
Spors, B.
Systematic Comparison of MRI and ultrasound scores to Assess Arthropathy in Children and Adolescents with Hemophilia
Sprogøe, U.
Case of Severe, Prolonged TTP - Course of Platelet Count, ADAMTS13 Enzyme Activity and Inhibitor Levels Over Time in Correlation to Treatment
Spronk, H.M.
The Relation between Coagulant and Vascular Function in Adult Survivors of Childhood Cancer
Srilatha, Tangada
Results from a Phase 3, Randomized, Multicenter Study of Rurioctocog alfa Pegol PK-Guided Prophylaxis Targeting 2 FVIII Trough Levels in Patients with Severe Hemophilia a (Propel Study)
Stachon, P.
Platelet-leukocyte Complex Formation is Associated with, but Dispensable for Myocardial Ischemia Reperfusion Injury
Stallmann, D.
The Inflammatory Landscape during Myocardial Reperfusion Injury Depends on Distinct Neutrophil Phenotypes
Stanford, S.
Fibrinogen Concentrate vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study
Stark, K.
Pancreatic Tumor Microvesicles Invade Immune Cells via CD36 and Distinctly Promote Tumor-associated Deep Vein Thrombosis
Starz, C.
Platelet-leukocyte Complex Formation is Associated with, but Dispensable for Myocardial Ischemia Reperfusion Injury
Stasyshyn, O.
Long-term Efficacy and Safety of rVIII-SingleChain in Patients with Severe Hemophilia A: Interim Results of an Extension Study
Staudinger, T.
Emicizumab for the Treatment of Acquired Hemophilia A: Lessons Learned from 4 very Different Cases
Stein, P.
A Universal Anti-Xa Assay for the Determination of Rivaroxaban and Apixaban Plasma Concentrations: An In vitro Investigation and Evaluation Study in Real-life Clinical Practice
Steiner, M.
A New Rapid, Specific, and Simple ELISA for von Willebrand Factor Propeptide
Stichel, D.
The Evolution of Antibody Response during Immune Tolerance INDUCTION IN PAtients with Severe Hemophilia A Predicts Outcome
Identification of Plasma Cytokine Levels Correlating with FVIII Inhibitor Titer during ITI
Affinities of FVIII-specific IgG1 and IgG4 during ITI
Stockschläder, A.
Successful Control of Bleeding with Emicizumab in Aquired Haemophilia A: A Case Report
Stoll, M.
Role of Gender and ABO-blood Group in White Adolescents and Young Adult Patients with First VTE Onset
Recurrent Pediatric Stroke: The Role of Thrombophilia in a Large International Pediatric Stroke Population
Recurrent Pediatric Stroke: The Role of Thrombophilia in a Large International Pediatric Stroke Population
Storozheva, M.
Nanosilver Induce Platelet Pro-thrombotic Ability in Norm and Pathology
Strasser, E.F.
Establishment of Various Specific Parameters for the Routine Diagnostics in Patients with Glanzmann Thrombasthenia
Sträter, R.
Recurrent Pediatric Stroke: The Role of Thrombophilia in a Large International Pediatric Stroke Population
Recurrent Pediatric Stroke: The Role of Thrombophilia in a Large International Pediatric Stroke Population
Straub, A.
A New Method to Assess Platelet Activation and Leukocyte-platelet Aggregates in Whole Blood Samples by Flow Cytometry for Clinical Studies
Acquired von Willebrand Syndrome during Mechanical Circulatory Support and Extracorporeal Membrane Oxygenation: Rapid Onset and the Demand for Point of Care Testing
Straussinsky, M.
Acquired von Willebrand Syndrome during Mechanical Circulatory Support and Extracorporeal Membrane Oxygenation: Rapid Onset and the Demand for Point of Care Testing
Streif, W.
Prevalence of Paroxysmal Nocturnal Hemoglobinuria in Children with Thrombosis - A Retrospective Cohort Study
Strobel, U.
Ticagrelor Inhibits the Functional Assay for Heparin-induced Thrombocytopenia
Studt, J.-D.
A Universal Anti-Xa Assay for the Determination of Rivaroxaban and Apixaban Plasma Concentrations: An In vitro Investigation and Evaluation Study in Real-life Clinical Practice
Stupar, A.
Correlation of Genotype and Phenotype in Congenital FXI Deficiency
Stuplich, C.
Severe Arterial Forearm Thrombosis in an 11-year-old Girl with Homozygous Antithrombin Deficiency typ IIb Budapest 3 and Mild Factor VII Deficiency Due to Homozygous Polymorphisms in the Factor 7 Gene and Antithrombotic Treatment
Sugiura, K.
Risk of Venous and Arterial Thromboembolism among Japanese Users of Oral Contraceptives
Sukkar, B.
Phosphate-induced ORAI1 Expression and Store Operated Ca
2+
Entry in Megakaryocytes
Sykora, K.-W.
The Evolution of Antibody Response during Immune Tolerance INDUCTION IN PAtients with Severe Hemophilia A Predicts Outcome
Szabó, G.
The Thrombin Generation Test: A Research Method or a Diagnostic Test?