A FHIR Human Leukocyte Antigen (HLA) Interface for Platelet Transfusion Support

William J Gordon; Jane Baronas; William J Lane

doi:10.4338/ACI-2017-01-CR-0010

Applied Clinical Informatics, Table of Contents

Appl Clin Inform 2017; 08(02): 603-611
DOI: 10.4338/ACI-2017-01-CR-0010

Case Report – Special Topic Interoperability and EHR

Schattauer GmbH

A FHIR Human Leukocyte Antigen (HLA) Interface for Platelet Transfusion Support

Authors

William J Gordon

¹Clinical Informatics and Innovation, Brigham and Women’s Hospital, Boston, MA

³Department of Medicine, Massachusetts General Hospital, Boston, MA

⁴Harvard Medical School, Boston, MA, USA
Jane Baronas

²Department of Pathology, Brigham and Women’s Hospital, Boston, MA
William J Lane

²Department of Pathology, Brigham and Women’s Hospital, Boston, MA

⁴Harvard Medical School, Boston, MA, USA

Abstract

Summary

Platelet transfusions are a cornerstone of therapy for patients who develop thrombocytopenia while undergoing Hematopoietic Stem Cell Transplantation (HSCT). Many patients who develop Platelet Transfusion Refractoriness (PTR) require HLA-matched platelets. Identifying these patients early could lead to better utilization of platelets as well as increased platelet counts. We built a SMART on FHIR visualization tool to aid the oncology, blood bank, and blood donor center teams in identifying these patients by showing trends in thrombocytopenia along with a computer generated calculated Panel Reactive Antibody (cPRA) level. To do this, we required a FHIR interface to our HLA database. We describe our methods and outcome for constructing this FHIR interface, as well as the architecture and data flow of HLA data from its proprietary database to the SMART on FHIR environment and application database along with RESTful cPRA web service calculator. Future work will evaluate the clinical impact of this platelet visualization tool and overall success of our FHIR implementation.

Citation: Gordon WJ, Baronas J, Lane WJ. A FHIR human leukocyte antigen (HLA) interface for platelet transfusion Support. Appl Clin Inform 2017; 8: 603–611 https://doi.org/10.4338/ACI-2017-01-CR-0010

Keywords

Laboratory information systems - standards - FHIR - HLA antigens - platelet transfusion

Full Text

References

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