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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2015; 32(04): 231-235
DOI: 10.4322/jms.065814
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Morphological alterations in the heart and aorta of rats treated with glucocorticoids

R. E. A. Dantas
1   Intracellular Signaling Research Nucleus, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
K. S. Souza
2   Laboratory of Hystology, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
D. M. Santos
1   Intracellular Signaling Research Nucleus, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
V. L. C. Feitosa
3   Laboratory of Cell Biology, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
E. T. Fioretto
2   Laboratory of Hystology, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
M. B. Aires
2   Laboratory of Hystology, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
,
A. C. Marçal
1   Intracellular Signaling Research Nucleus, Department of Morphology, Universidade Federal de Sergipe - UFS, Av. Marechal Rondon, s/n, CEP 49100-000, São Cristóvão, SE, Brazil
› Author Affiliations
Further Information

Publication History

14 May 2015

15 February 2016

Publication Date:
10 October 2018 (online)

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Abstract

Introduction: The objective of this study was to analyze the morphological structure of the heart and aorta of rats treated with the synthetic glucocorticoid dexamethasone. Material and Methods: Male Wistar rats were divided into two groups: 08 control rats undergoing treatment with a 0.9% saline solution for 10 days and 08 rats treated for 10 days with dexamethasone (2mg/kg animal weight). Results: Histological analysis detected a mild cardiac hypertrophy and 15% reduction of collagen located in the aorta of animals treated with glucocorticoid when compared to the control group. Conclusion: We conclude that treatment with dexamethasone for a period of 10 consecutive days is able to promote morphological changes in the structure of the heart chamber and, impair morphological structure of aorta.

Keywords

glucocorticoids - artery - heart - rat