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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2014; 31(02): 082-088
DOI: 10.4322/jms.058313
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration

A. A. Akinlolu
1   PhD Anatomy (in-view), Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria
,
K. O. Ghazali
2   PhD AAnatomy (in-view), Department of Anatomy, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria
,
O. M. Ameen
3   PhD Chemistry (in-view), Department of AAnatomy, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria
,
A. O. Odewabi
4   Higher National Diploma (Medical Laboratory Sciences), M.Sc Biochemistry, Olabisi Onabanjo University Teaching Hospital, AAkarigbo Street, Shagamu, Ogun State, Nigeria
› Author Affiliations
Further Information

Publication History

15 July 2013

20 May 2014

Publication Date:
08 October 2018 (online)

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Abstract

Introduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II - VI. Four hours after administrations of the ulcerogen; rats of Groups III - VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III - VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: AAnalyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III - VI. Histo-pathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III - VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin - induced gastric ulceration.

Keywords

spondias mombin - indomethacin - stomach - ulceration - rats