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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2014; 31(02): 082-088
DOI: 10.4322/jms.058313
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration

Authors

  • A. A. Akinlolu

    1   PhD Anatomy (in-view), Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria

  • K. O. Ghazali

    2   PhD AAnatomy (in-view), Department of Anatomy, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria

  • O. M. Ameen

    3   PhD Chemistry (in-view), Department of AAnatomy, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria

  • A. O. Odewabi

    4   Higher National Diploma (Medical Laboratory Sciences), M.Sc Biochemistry, Olabisi Onabanjo University Teaching Hospital, AAkarigbo Street, Shagamu, Ogun State, Nigeria
Further Information

Publication History

15 July 2013

20 May 2014

Publication Date:
08 October 2018 (online)

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Abstract

Introduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II - VI. Four hours after administrations of the ulcerogen; rats of Groups III - VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III - VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: AAnalyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III - VI. Histo-pathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III - VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin - induced gastric ulceration.

Keywords

spondias mombin - indomethacin - stomach - ulceration - rats