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CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(03): 195-197
DOI: 10.4103/sajc.sajc_314_18
ORIGINAL ARTICLE: Pediatric and Adolescent Cancers

Retinoblastoma: A retrospective analysis of 141 patients from 1983 to 2013 at a tertiary care hospital in Nagpur, India

Rohit S. Kabre
Department of Radiation Oncology, P.D. Hinduja Hospital, Mumbai, Maharashtra
,
Krishna M. Kamble
Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Purpose: There is scarcity of data regarding clinical presentation and outcome of retinoblastoma patients in India. Objectives: The objective of this study was to assess the clinical profile of retinoblastoma patients in a tertiary care hospital in India from 1983 to 2013. Subjects and Methods: A retrospective analysis of clinical records of 141 patients with retinoblastoma registered from 1983 to 2013 at Government Medical College, Nagpur, India, was conducted. Demographics, clinical features, modes of treatment, and outcome of the patients were assessed. Results: Majority of patients (81 [57.45%]) presented in the age group of 1–3 years and were males. One hundred and fourteen patients (80.85%) had unilateral disease, while rare presentations of trilateral/quadrilateral retinoblastoma were also noted. Proptosis was seen in 81 (57.45%) patients as presenting symptom. Eighty-nine patients (63.12%) had locally invasive disease-involving sites. Forty-four patients (31.19%) developed distant metastasis. Surgical management and external beam radiotherapy were followed in majority of patients. Trend of increased usage of chemotherapy was seen from the mid-1990s. One hundred and twelve patients (79.43%) died with the disease. Conclusions: Data from this study show late diagnosis, leading to poor outcome for patients with advanced retinoblastoma, which is in accordance with data from other developing countries. Even though management of patients changed in accordance with changing standard of care over the decade, mortality remained high.

Key words

Advanced stage - changing trend - retinoblastoma


Publication History

Article published online:
21 December 2020

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