Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(03): 171-173
DOI: 10.4103/0971-5851.92823
CASE REPORT

Paravaginal peripheral primitive neuroectodermal tumor: A rare tumor

Samrat Dutta
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India
,
Chandan Dasgupta
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India
,
Kakoli Choudhury
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India
› Author Affiliations
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

Peripheral primitive neuroectodermal tumor (PNET) of the female genital tract, particularly those in the vaginal and paravaginal region, are extremely rare. A 36-year-old woman presented with clinical features similar to that of a case of cervical fibroid. It was only after surgery that the histopathology suggested it to be a malignant round cell tumour and was CD99 positive. She underwent adjuvant chemotherapy with the Ifosfamide and Etoposide alternating with Vincristine, Doxorubicin, and Cyclophosphamide regime and radical radiotherapy. She is disease free at 12 months of follow-up. The importance of immunostaining and adequate histopathology report lies in the fact that the correct diagnosis thus achieved enabled us to manage a rare case of paravaginal PNET with a multimodality approach.

Keywords

Immunostain - primitive neuroectodermal tumor - vagina


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Angervall L, Enzinger FM. Extraskeletal neoplasm resembling Ewing′s sarcoma. Cancer 1975;36:240-51.
  • 2 Blattner JM, Gable P, Quigley MM, McHale MT. Primitive Neuroectodermal tumour of uterus. Gynecol Oncol 2007;106:419-22.
  • 3 McCluggage WG, Sumathi VP, Nucci MR, Hirsch M, Dal Cin P, Wells M, et al. Ewing family of tumours involving the vulva and vagina: Report of a series of four cases. J Clin Pathol 2007:60:674-80.
  • 4 Liao X, Xin X, Lü X. Primary Ewing′s sarcoma-primitive neuroectodermal tumor of the vagina. Gynecol Oncol 2004;92:684-8.
  • 5 Al-Tamimi H, Al-Hadi AA, Al-Khater AH, Al-Bozom I, Al-Sayed N. Extraskeletal neuroectodermal tumour of the vagina: A single case report and review. Arch Gynecol Obstet 2009;280:465-8.
  • 6 Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing′s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348:694-701.
  • 7 Farley J, O′Boyle JD, Heaton J, Remmenga S. Extraosseous Ewing′s sarcoma of the vagina. Obstet Gynecol 2000;96:832-4.
  • 8 Daya D, Lukka H, Clement PB. Primitive neuroectodermal tumors of the uterus: A report of four cases. Hum Pathol 1992;23:1120-9.
  • 9 Cenacchi G, Pasquinelli G, Montanaro L, Cerasoli S, Vici M, Bisceglia M, et al. Primary endocervical extraosseous Ewing sarcoma/PNET. Int J Gynecol Pathol 1998;17:83--8.