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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2008; 29(03): 2-6
DOI: 10.4103/0971-5851.51413
Original Article

Epstein-barr virus in gastric lymphoma- An Indian perspective

Abhay Sood
Department of Pathology, St. John′s Medical College, Bangalore - 560034, India
,
Abhita Braganza
Department of Pathology, St. John′s Medical College, Bangalore - 560034, India
,
T Rajalakshmi
Department of Pathology, St. John′s Medical College, Bangalore - 560034, India
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Abstract

Background: Primary Gastric Non- Hodgkin′s Lymphomas (NHL) are being increasingly encountered in the recent years. While the role of Helicobacter pylori (H. pylori) has been explored in its causation, some studies have suggested the role of the Epstein - Barr virus (EBV). However data from India is not readily available and this prompted us to study the morphology of primary gastric NHL, the prevalence of EBV infection in primary Gastric NHL and study its association with H. pylori infection. Materials& Methods: A retrospective study. Sixteen biopsy proven cases of primary gastric NHL were studied. Histologic features were reviewed. Immunohistochemistry for EBV LMP-1 and Modified Giemsa stain to identify Helicobacter pylori were done. Results: There were 10 low-grade and 6 highgrade lymphomas, 15 of them classifiable as Mucosa-associated lymphoid tissue (MALT) type, owing to the presence of lymphoepithelial lesions. 36% of the cases were EBV positive. Only one case showed H. pylori. 4 patients succumbed to the disease, of which 3 were seropositive for HIV. Conclusion: Our pilot study suggests that EBV may have an important role in the pathogenesis of gastric MALT lymphomas. The significance of this association and its prognostic value need to be explored in larger number of patients.



Publikationsverlauf

Artikel online veröffentlicht:
02. März 2022

© 2008. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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