CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2015; 36(04): 255-260
DOI: 10.4103/0971-5851.171550
ORIGINAL ARTICLE

Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution

Rahul Narayan Maddi
Department of Medical Oncology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, India
,
Vijay Gandhi Linga
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Kalpathi Krishnamani Iyer
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Joseph Stalin Chowdary
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Sadashivudu Gundeti
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Raghunadharao Digumarti
Director and Department of Medical Oncology, Tata Memorial Center, Vishakapatnam, Andhra Pradesh, India
,
Tara Roshini Paul
Department of Pathology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse. Aims: Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities. Settings and Design: This is a retrospective analysis from the case records from a single institution. Materials and Methods: Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age ≥18 years) underwent treatment at our institution. Statistical Analysis: Kaplan-Meyer curves were used to calculate the PFS and OS. Results: The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%). Conclusions: Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively.



Publication History

Publication Date:
12 July 2021 (online)

© 2015. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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