Yearb Med Inform 2017; 26(01): 38-52
DOI: 10.15265/IY-2017-007
Special Section: Learning from Experience: Secondary Use of Patient Data
Working Group Contributions
Georg Thieme Verlag KG Stuttgart

Clinical Data Reuse or Secondary Use: Current Status and Potential Future Progress

S. M. Meystre
a  Medical University of South Carolina, Charleston, SC, USA
C. Lovis
b  Division of Medical Information Sciences, University Hospitals of Geneva, Switzerland
T. Bürkle
c  University of Applied Sciences, Bern, Switzerland
G. Tognola
d  Institute of Electronics, Computer and Telecommunication Engineering, Italian Natl. Research Council IEIIT-CNR, Milan, Italy
A. Budrionis
e  Norwegian Centre for E-health Research, University Hospital of North Norway, Tromsø, Norway
C. U. Lehmann
f  Departments of Biomedical Informatics and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
› Author Affiliations
Further Information

Publication History

08 May 2017

Publication Date:
11 September 2017 (online)



Objective: To perform a review of recent research in clinical data reuse or secondary use, and envision future advances in this field.

Methods: The review is based on a large literature search in MEDLINE (through PubMed), conference proceedings, and the ACM Digital Library, focusing only on research published between 2005 and early 2016. Each selected publication was reviewed by the authors, and a structured analysis and summarization of its content was developed.

Results: The initial search produced 359 publications, reduced after a manual examination of abstracts and full publications. The following aspects of clinical data reuse are discussed: motivations and challenges, privacy and ethical concerns, data integration and interoperability, data models and terminologies, unstructured data reuse, structured data mining, clinical practice and research integration, and examples of clinical data reuse (quality measurement and learning healthcare systems).

Conclusion: Reuse of clinical data is a fast-growing field recognized as essential to realize the potentials for high quality healthcare, improved healthcare management, reduced healthcare costs, population health management, and effective clinical research.