TY - JOUR AU - Meystre, S. M.; Lovis, C.; Bürkle, T.; Tognola, G.; Budrionis, A.; Lehmann, C. U. TI - Clinical Data Reuse or Secondary Use: Current Status and Potential Future Progress SN - 0943-4747 SN - 2364-0502 PY - 2017 JO - Yearb Med Inform JF - Yearbook of Medical Informatics LA - EN VL - 26 IS - 01 SP - 38 EP - 52 DA - 2017/09/11 KW - Medical informatics KW - electronic health records KW - health services research KW - health care evaluation mechanisms KW - clinical studies as topic AB - Objective: To perform a review of recent research in clinical data reuse or secondary use, and envision future advances in this field.Methods: The review is based on a large literature search in MEDLINE (through PubMed), conference proceedings, and the ACM Digital Library, focusing only on research published between 2005 and early 2016. Each selected publication was reviewed by the authors, and a structured analysis and summarization of its content was developed.Results: The initial search produced 359 publications, reduced after a manual examination of abstracts and full publications. The following aspects of clinical data reuse are discussed: motivations and challenges, privacy and ethical concerns, data integration and interoperability, data models and terminologies, unstructured data reuse, structured data mining, clinical practice and research integration, and examples of clinical data reuse (quality measurement and learning healthcare systems).Conclusion: Reuse of clinical data is a fast-growing field recognized as essential to realize the potentials for high quality healthcare, improved healthcare management, reduced healthcare costs, population health management, and effective clinical research. PB - Georg Thieme Verlag KG DO - 10.15265/IY-2017-007 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.15265/IY-2017-007 ER -