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CC BY 4.0 · Aorta (Stamford) 2016; 04(06): 219-225
DOI: 10.12945/j.aorta.2016.16.025
Original Research Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Asymmetric Dimethylarginine in Patients with Ascending Aortic Aneurysms

Natalia D. Gavriliuk
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Tatiana A. Druzhkova
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Olga B. Irtyuga
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Alexandr A. Zhloba
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
2   Department of Biochemistry, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Tatiana F. Subbotina
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
2   Department of Biochemistry, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Vladimir E. Uspenskiy
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Nina P. Alexeyeva
3   Department of Medical Statistics, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Olga M. Moiseeva
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
› Author Affiliations
Further Information

Publication History

13 May 2016

24 October 2016

Publication Date:
24 September 2018 (online)

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Abstract

Background: Ascending thoracic aortic aneurysm (aTAA) is a heterogeneous group of disorders that involve impaired endothelial function. The nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) serves as an endothelial dysfunction marker. Thus, we investigated ADMA levels in patients with aTAA.

Methods: Eighty-six patients with aTAA and 18 healthy individuals were enrolled. All patients underwent echocardiography. Plasma ADMA levels were measured using high-performance liquid chromatography.

Results: ADMA levels were higher in aTAA patients than in control patients (p = 0.034). According to the multivariable regression model, higher ADMA levels were associated with ascending aortic diameter (p = 0.017), smoking (p = 0.016), and log-transformed estimated glomerular filtration rate (eGFR, p = 0.005).

Conclusion: This pilot study demonstrates an association of ADMA with ascending aortic dilatation; however, further studies are needed to investigate whether increased ADMA levels underlie aTAA development.

Key Words

Asymmetric dimethylarginine - Thoracic aortic aneurysm - Endothelial dysfunction
 

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