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CC BY 4.0 · Aorta (Stamford) 2013; 01(06): 259-267
DOI: 10.12945/j.aorta.2013.13-044
Original Research Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Inflammatory Cell Infiltrates in Acute and Chronic Thoracic Aortic Dissection

Darrell Wu   †
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
3   Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas
,
Justin C. Choi   †
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
,
Aryan Sameri
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
,
Charles G. Minard
4   Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas
,
Joseph S. Coselli
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
,
Ying H. Shen
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
,
Scott A. LeMaire
1   Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas
3   Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas
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Publikationsverlauf

22. August 2013

27. November 2013

Publikationsdatum:
28. September 2018 (online)

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Abstract

Background: Thoracic aortic dissection (TAD) is a highly lethal cardiovascular disease. Injury to the intima and media allows pulsatile blood to enter the media, leading to dissection formation. Inflammatory cells then infiltrate the site of aortic injury to clear dead cells and damaged tissue. This excessive inflammation may play a role in aneurysm formation after dissection.

Methods: Using immunohistochemistry, we compared aortic tissues from patients with acute TAD (n = 11), patients with chronic TAD (n = 35), and donor controls (n = 20) for the presence of CD68+ macrophages, neutrophils, mast cells, and CD3+ T lymphocytes.

Results: Tissue samples from patients with acute or chronic TAD generally had significantly more inflammatory cells in both the medial and adventitial layers than did the control samples. In tissues from patients with acute TAD, the adventitia had more of the inflammatory cells studied than did the media. The pattern of increase in inflammatory cells was similar in chronic and acute TAD tissues, except for macrophages, which were seen more frequently in the adventitial layer of acute TAD tissue than in the adventitia of chronic TAD tissue.

Conclusions: The inflammatory cell content of both acute and chronic TAD tissue was significantly different from that of control tissue. However, the inflammatory cell profile of aneurysmal chronic TAD was similar to that of acute TAD. This may reflect a sustained injury response that contributes to medial degeneration and aneurysm formation.

Key Words

Inflammation - Thoracic aortic dissection - Macrophage - Mast cell - Neutrophil - T lymphocyte

† These authors contributed equally to this study.


 

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