Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 2011; 106(03): 561-562
DOI: 10.1160/TH11-04-0275
DOI: 10.1160/TH11-04-0275
Letters to the Editor
Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells
Authors
Further Information
Publication History
Received: 28 April 2011
Accepted after major revision: 15 June 2011
Publication Date:
24 November 2017 (online)
-
References
- 1 Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 2007; 27: 1687-1693.
- 2 Brummel KE, Paradis SG, Butenas S. et al. Thrombin functions during tissue factor-induced blood coagulation. Blood 2002; 100: 148-152.
- 3 Mutch NJ, Robbie LA, Booth NA. Human thrombi contain an abundance of active thrombin. Thromb Haemost 2001; 86: 1028-1034.
- 4 Schrör K, Bretschneider E, Fischer K. et al. Thrombin receptors in vascular smooth muscle cells – function and regulation by vasodilatory prostaglandins. Thromb Haemost 2010; 103: 884-890.
- 5 Bretschneider E, Braun M, Fischer A. et al. Factor Xa acts as a PDGF-independent mitogen in human vascular smooth muscle cells. Thromb Haemost 2000; 84: 499-505.
- 6 McNamara CA, Sarembock IJ, Gimple LW. et al. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 1993; 91: 94-98.
- 7 Rauch BH, Millette E, Kenagy RD. et al. Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ Res 2004; 94: 340-345.
- 8 Koo BH, Chung KH, Hwang KC. et al. Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2. FEBS Lett 2002; 523: 85-89.
- 9 Hemker HC, Giesen P, Al Dieri R. et al. The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. Pathophysiol Haemost Thromb 2002; 32: 249-253.
- 10 Rosenkranz AC, Rauch BH, Freidel K. et al. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res 2009; 83: 778-784.
- 11 Rauch SJ, Rosenkranz AC, Böhm A. et al. Cholesterol induces apoptosis-associated loss of the activated leukocyte cell adhesion molecule (ALCAM) in human monocytes. Vascul Pharmacol 2011; 54: 93-99.