Summary
The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its
main ligand VWF play a key role in the adhesion process of platelets to sites of vascular
injury. Recent studies in mutant mice have shed new light on the importance of either
molecule for the development of arterial and venous thrombosis. In this review, we
summarize the most important aspects from these studies.
Keywords
Thrombosis - glycoprotein - vonWillebrand factor - mutant - mice