Thromb Haemost 2008; 99(01): 238-239
DOI: 10.1160/TH07-08-0486
Letters to the Editor
Schattauer GmbH

Report on a disease-adapted treatment in a patient with severe factor X deficiency resulting from a homozygous factor X gene mutation

Andrea Gerhardt
1   Department of Hemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany
,
Fatima Araba
1   Department of Hemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany
,
Rüdiger E Scharf
1   Department of Hemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany
,
Rainer B Zotz
1   Department of Hemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany
› Author Affiliations
Further Information

Publication History

Received: 02 August 2007

Accepted after major revision: 11 October 2007

Publication Date:
24 November 2017 (online)

 

 
  • References

  • 1 Herrmann FH, Auerswald G, Ruiz-Saez A. et al. The Greifswald Factor X Deficiency Study Group. Factor X deficiency: clinical manifestation of 102 subject from Europe and Latin America with mutations in the factor 10 gene. Haemophilia 2006; 12: 479-489.
  • 2 Dewerchin M, Liang Z, Moons L. et al. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost 2000; 83: 185-190.
  • 3 Al-Hilal A, Wulff K, Abdel-Razeq H. et al. Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyad anomaly. Thromb Haemost 2007; 97: 542-545.
  • 4 Peyvandi F, Menegatti M, Santagostino E. et al. Gene mutations and three-dimensional structural analysis in 13 families with severe Factor X deficiency. Br J Haematol 2002; 117: 685-692.
  • 5 Todd T, Perry DJ, Hayman E. et al. Severe factor X deficiency due to a homozygous mutation (Cys364Arg) that disrupts a disulphide bond in the catalytic domain. Haemophilia 2006; 12: 621-624.
  • 6 Kohler M. Thrombogenicity of prothrombin complex concentrates. Thromb Res 1999; 95: S13-17.