Fibrinogen-binding proteins of Gram-positive bacteria

Jose Rivera; Ganesh Vannakambadi; Magnus Höök; Pietro Speziale

doi:10.1160/TH07-03-0233

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(03): 503-511
DOI: 10.1160/TH07-03-0233

Theme Issue Article

Schattauer GmbH

Fibrinogen-binding proteins of Gram-positive bacteria

Jose Rivera

¹Institute of Biosciences and Technology, Center for Extracellular and Matrix Biology, Houston, Texas, USA

,

Ganesh Vannakambadi

¹Institute of Biosciences and Technology, Center for Extracellular and Matrix Biology, Houston, Texas, USA

,

Magnus Höök

¹Institute of Biosciences and Technology, Center for Extracellular and Matrix Biology, Houston, Texas, USA

,

Pietro Speziale

²Department of Biochemistry, University of Pavia, Pavia, Italy

› Author Affiliations

Abstract

Summary

Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis. In addition, this 340 kD glycoprotein is a stress inducible protein; its synthesis is dramatically upregulated during inflammation or under exposure to stress such systemic infections.This regulation of Fg expression indicates that Fg also participates in the host defense system against infections. In fact, a number of reported studies have demonstrated the involvement of both the intrinsic and extrinsic pathways of coagulation; the thrombotic and the fibrinolytic systems in the pathophysiology of infectious diseases. It is, therefore, perhaps not surprising that many pathogenic bacteria can interact with Fg and manipulate its biology.This review focuses on the major Fg-binding proteins (Fgbps) from Gram-positive bacteria with an emphasis on those that are known to have an effect on coagulation and thrombosis

Keywords

Bacterial infection - infectious diseases - bacteria - fibrinogen / fibrin - protein function / activity

Full Text

References

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