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Synfacts 2008(9): 1007-1007  
DOI: 10.1055/s-2008-1078653
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Silica-Supported Alkyne Metathesis Catalyst: Synthetic Application

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
H. M. Cho, H. Weissman, J. S. Moore*
University of Illinois at Urbana-Champaign, USA
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

A silica-supported molybdenum complex 2 was prepared and found to promote ring-closing alkyne metathesis (RCAM). Thus, the reaction of trisamidomolybdenum(VI) complex 1 with fumed silica in trichlorobenzene gave molybdenum catalyst 2. The RCAM of diyne 3 was carried out under reduced pressure conditions (1 mmHg to remove 3-hexyne) in the presence of 5 mol% Mo of the catalyst 2 to give cyclic product 4 in 62% yield. The RCAM of several diynes gave the corresponding cyclic products in good yield (3 examples: 65-67% yield).