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Synfacts 2008(9): 0960-0960  
DOI: 10.1055/s-2008-1078642
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Pd-Catalyzed Allylation of Fluorinated Allyl Enol Carbonates

Contributor(s): Mark Lautens, Valentina Aureggi
É. Bélanger, C. Houzé, N. Guimond, K. Cantin, J.-F. Paquin*
University of Laval, Québec, Canada
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Fluorine-containing molecules are important building blocks in medicinal chemistry. Fluorinated substrates often show different reactivity compared to their non-fluorinated analogues. Therefore, the development of new reaction conditions for fluorinated compounds is still an important challenge in synthetic chemistry. Herein, the efficient enantioselective Pd-catalyzed allylation of fluorinated allyl enol carbonates is reported.