Rh-Catalyzed Enantioselective Addition of Arylboronic Acids
to Aliphatic Imines

doi:10.1055/s-2008-1078639

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Synfacts 2008(9): 0948-0948
DOI: 10.1055/s-2008-1078639

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Rh-Catalyzed Enantioselective Addition of Arylboronic Acids to Aliphatic Imines

Contributor(s): Mark Lautens, Valentina Aureggi
M. Trincado, J. A. Ellman*
University of California, Berkeley, USA

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Publication History

Publication Date:
22 August 2008 (online)

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Significance

The enantioselective catalytic addition of arylboronic acids to aliphatic imines is reported. The corresponding α-aryl alkylamines are obtained with excellent yields and enantioselectivities. This work represents one of the few examples of boronic acid addition to aliphatic imines.