Negishi Cross-Couplings of Unprotected Phenols, Anilines, and Alcohols

Significance

The Pd-catalyzed cross-coupling reactions are now among the most widely used synthetic methods in organic chemistry. Organo­zinc reagents are in general more reactive than the corresponding boron compounds, and at the same time are seemingly incompatible with acidic protons in the reaction mixture. A careful choice of the catalyst and reaction conditions allowed performing the cross-coupling of unprotected phenols, alcohols and anilines that greatly broadened the scope of substrates, suitable for the Negishi cross-coupling reaction.