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Synfacts 2008(8): 0846-0846  
DOI: 10.1055/s-2008-1078560
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Addition of Arylboronic Acids to a-Keto Esters

Contributor(s): Hisashi Yamamoto, Pingfan Li
H.-F. Duan, J.-H. Xie, X.-C. Qiao, L.-X. Wang, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
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Publikationsdatum:
23. Juli 2008 (online)

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Significance

The current work represents the first example of catalytic enantioselective addition of arylboronic acids to α-keto esters to provide α-hydroxy esters with good yields and high enan­tiomeric excess. The reaction is conducted in aqueous solution at room temperature or 0 ˚C with 3 mol% rhodium loading.