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Synthesis of (+)-Superstolide A
M. Tortosa, N. A. Yakelis, W. R. Roush*
Scripps Florida, Jupiter and University of Michigan, Ann Arbor, USA
23 July 2008 (online)
Superstolide A is a macrolide found in the sponge Neosiphonia superstes. It showed high activity against several cancer cell lines. The noteworthy step of the synthesis is an intramolecular Diels-Alder reaction in the 24-membered macrocycle I; this route is also likely to be biomimetic.