Synfacts 2008(8): 0786-0786  
DOI: 10.1055/s-2008-1078534
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Superstolide A

Contributor(s): Philip Kocienski, Zofia Komsta
M. Tortosa, N. A. Yakelis, W. R. Roush*Scripps Florida, Jupiter and University of Michigan, Ann Arbor, USA
Further Information

Publication History

Publication Date:
23 July 2008 (online)

Significance

Superstolide A is a macrolide found in the sponge Neosiphonia superstes. It showed high activity against several cancer cell lines. The noteworthy step of the synthesis is an intramolecular Diels-Alder reaction in the 24-membered macrocycle I; this route is also likely to be biomimetic.