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Synfacts 2008(8): 0859-0859  
DOI: 10.1055/s-2008-1078521
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Highly Efficient Catalyst for Pd-Catalyzed Amination of Aryl Halides

Contributor(s): Paul Knochel, Tobias Thaler
Q. Sheng, T. Ogata, J. F. Hartwig*
Yale University, New Haven and University of Illinois, Urbana, USA
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

This article presents an extensive study on the selectivity, scope and structure-activity relations for the Pd-catalyzed amination of (het)aryl halides with primary amines. Aryl iodies, which are known to be more reluctant substrates to Pd-catalyzed amination, were also successfully converted.