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Synfacts 2008(6): 0620-0620  
DOI: 10.1055/s-2008-1078395
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd(II)-Catalyzed Cyclization of Allenyl Aldeydes with Arylboronic Acids

Contributor(s): Mark Lautens, Valentina Aureggi
H. Tsukamoto*, T. Matsumoto, Y. Kondo
Tohoku University, Sendai, Japan
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Publication History

Publication Date:
21 May 2008 (online)

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Significance

The development of a Pd-catalyzed enantioselective cyclization of allenyl aldehydes with arylboronic acids is reported. The cis-cyclic homoallylic alcohols are obtained in good yields with excellent enantio- and diastereoselectivities.