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Synfacts 2008(9): 0956-0956
DOI: 10.1055/s-2008-1078006
DOI: 10.1055/s-2008-1078006
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Asymmetric Baeyer-Villiger Oxidation
A. V. Malkov*, F. Friscourt, M. Bell, M. E. Swarbrick, P. Kočovský*
University of Glasgow and GlaxoSmithKline, Harlow, UK
Further Information
Publication History
Publication Date:
22 August 2008 (online)
Significance
The authors reported the asymmetric Baeyer-Villiger
oxidation of symmetrical cyclobutanones with urea-hydrogen
peroxide in the presence of Pd(II) and a new terpene-derived
P,N-ligand.
The resulting lactones were obtained in high yields and with good
enantioselectivities.