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Synfacts 2008(9): 0909-0909  
DOI: 10.1055/s-2008-1077993
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Cylindricine C

Contributor(s): Philip Kocienski, Arndt W. Schmidt
A. C. Flick, M. J. Arevalo Caballero, A. Padwa*
Emory University, Atlanta, USA
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Cylindricines attracted considerable synthetic interest due to their challenging per­hydro pyrrolo[2,1-j]quinoline framework. A new access to (±)-cyclindricine C is reported using a Michael addition-dipolar cycloaddition sequence to construct the indolizidine core.