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Synfacts 2008(7): 0747-0747  
DOI: 10.1055/s-2008-1077829
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Rhodium(I)-Catalyzed Hydration of Organonitriles

Contributor(s): Paul Knochel, Tobias Thaler
A. Goto, K. Endo, S. Saito*
Nagoya University, Japan
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

A very general and efficient procedure for the hydration of organonitriles under very mild conditions using [{Rh(OMe)(cod)2}] as catalyst is presented in this article. The reaction proceeds with tolerance of a broad range of functional groups and with a good preservation of the stereochemical information. This hydration grants a straightforward and general access to a broad range of organonitriles.